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Tead4 TEA domain family member 4 [ Mus musculus (house mouse) ]

Gene ID: 21679, updated on 27-Aug-2018

Summary

Official Symbol
Tead4provided by MGI
Official Full Name
TEA domain family member 4provided by MGI
Primary source
MGI:MGI:106907
See related
Ensembl:ENSMUSG00000030353 Vega:OTTMUSG00000022461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tef3; Tefr; Etfr2; FR-19; Rtef1; TEF-3; Tefr1; ETFR-2; TEAD-4; Tefr1a; Tcf13r1
Summary
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. This factor may play a role in the embryonic development of skeletal muscle. Alternatively spliced transcripts encoding distinct isoforms, which are translated through the use of a non-AUG (AUU) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta adult (RPKM 4.9), lung adult (RPKM 4.8) and 15 other tissues See more
Orthologs

Genomic context

See Tead4 in Genome Data Viewer
Location:
6 F3; 6 62.92 cM
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (128227143..128300813, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (128177161..128250831, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene membrane bound O-acyltransferase domain containing 2 pseudogene Neighboring gene predicted gene 8703 Neighboring gene ribosomal protein L18, pseudogene 2 Neighboring gene tubby-like protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
blastocyst formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
trophectodermal cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcriptional enhancer factor TEF-3
Names
ETF-related factor-2
FGF-regulated 19
RTEF-1
TEF-1-related factor 1
TEF-1-related factor FR-19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080979.1NP_001074448.2  transcriptional enhancer factor TEF-3 isoform b

    See identical proteins and their annotated locations for NP_001074448.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (b, also known as ETFR-2b) that lacks an internal segment, compared to isoform a. It also initiates translation from a non-AUG (AUU) codon.
    Source sequence(s)
    AB221623, D87965, D87966, X94441
    Consensus CDS
    CCDS39645.1
    UniProtKB/Swiss-Prot
    Q62296
    Related
    ENSMUSP00000107784.2, OTTMUSP00000025559, ENSMUST00000112157.3, OTTMUST00000053724
    Conserved Domains (1) summary
    smart00426
    Location:3198
    TEA; TEA domain
  2. NM_011567.2NP_035697.3  transcriptional enhancer factor TEF-3 isoform a

    See identical proteins and their annotated locations for NP_035697.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a, also known as ETFR-2a), and initiates translation from a non-AUG (AUU) codon.
    Source sequence(s)
    AB221623, BC130257, D87965, D87966
    Consensus CDS
    CCDS39646.1
    UniProtKB/Swiss-Prot
    Q62296
    Related
    ENSMUSP00000006311.6, OTTMUSP00000025555, ENSMUST00000006311.12, OTTMUST00000053720
    Conserved Domains (1) summary
    smart00426
    Location:3198
    TEA; TEA domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    128227143..128300813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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