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Tead4 TEA domain family member 4 [ Mus musculus (house mouse) ]

Gene ID: 21679, updated on 16-Oct-2021

Summary

Official Symbol
Tead4provided by MGI
Official Full Name
TEA domain family member 4provided by MGI
Primary source
MGI:MGI:106907
See related
Ensembl:ENSMUSG00000030353
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tef3; Tefr; Etfr2; FR-19; Rtef1; TEF-3; Tefr1; ETFR-2; TEAD-4; Tefr1a; Tcf13r1
Summary
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. This factor may play a role in the embryonic development of skeletal muscle. Alternatively spliced transcripts encoding distinct isoforms, which are translated through the use of a non-AUG (AUU) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta adult (RPKM 4.9), lung adult (RPKM 4.8) and 15 other tissues See more
Orthologs
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Genomic context

See Tead4 in Genome Data Viewer
Location:
6 F3; 6 62.92 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128204106..128277776, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128227143..128300813, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (128177161..128250831, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene membrane bound O-acyltransferase domain containing 2 pseudogene Neighboring gene predicted gene 8703 Neighboring gene ribosomal protein L18, pseudogene 2 Neighboring gene tubby-like protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within trophectodermal cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcriptional enhancer factor TEF-3
Names
ETF-related factor-2
FGF-regulated 19
RTEF-1
TEF-1-related factor 1
TEF-1-related factor FR-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080979.1NP_001074448.2  transcriptional enhancer factor TEF-3 isoform b

    See identical proteins and their annotated locations for NP_001074448.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (b, also known as ETFR-2b) that lacks an internal segment, compared to isoform a. It also initiates translation from a non-AUG (AUU) codon.
    Source sequence(s)
    AB221623, D87965, D87966, X94441
    Consensus CDS
    CCDS39645.1
    UniProtKB/Swiss-Prot
    Q62296
    Related
    ENSMUSP00000107784.3, ENSMUST00000112157.4
    Conserved Domains (1) summary
    smart00426
    Location:3198
    TEA; TEA domain
  2. NM_011567.2NP_035697.3  transcriptional enhancer factor TEF-3 isoform a

    See identical proteins and their annotated locations for NP_035697.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a, also known as ETFR-2a), and initiates translation from a non-AUG (AUU) codon.
    Source sequence(s)
    AB221623, BC130257, D87965, D87966
    Consensus CDS
    CCDS39646.1
    UniProtKB/Swiss-Prot
    Q62296
    Related
    ENSMUSP00000006311.7, ENSMUST00000006311.13
    Conserved Domains (1) summary
    smart00426
    Location:3198
    TEA; TEA domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    128204106..128277776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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