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Sry sex determining region of Chr Y [ Mus musculus (house mouse) ]

Gene ID: 21674, updated on 29-Jan-2023

Summary

Official Symbol
Sryprovided by MGI
Official Full Name
sex determining region of Chr Yprovided by MGI
Primary source
MGI:MGI:98660
See related
Ensembl:ENSMUSG00000069036 AllianceGenome:MGI:98660
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tdf; Tdy
Summary
Enables DNA binding activity, bending and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in male sex determination. Acts upstream of or within male gonad development; negative regulation of gene expression; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including brain; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in 46,XX sex reversal 1; 46,XY sex reversal; and 46,XY sex reversal 1. Orthologous to human SRY (sex determining region Y). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Sry in Genome Data Viewer
Location:
Y; Ypter
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (2662471..2663658, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (2662471..2663658, complement)

Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene H2A histone family member L2C Neighboring gene ubiquitin-activating enzyme, Chr Y, pseudogene 1 Neighboring gene Sry promoter region Neighboring gene ubiquitin-activating enzyme E1, Chr Y 1 pseudogene Neighboring gene H2A histone family member L2B

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC129295

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within male gonad development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in male gonad development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in male sex determination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within male sex determination IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of male gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in sex determination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sex determination IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within sex differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sex-determining region Y protein
Names
testis determining-Y
testis-determining factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011564.1NP_035694.1  sex-determining region Y protein

    See identical proteins and their annotated locations for NP_035694.1

    Status: PROVISIONAL

    Source sequence(s)
    X67204
    Consensus CDS
    CCDS30545.1
    UniProtKB/Swiss-Prot
    Q05738
    UniProtKB/TrEMBL
    Q53WV7
    Related
    ENSMUSP00000088717.2, ENSMUST00000091178.2
    Conserved Domains (1) summary
    cd01388
    Location:474
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000087.8 Reference GRCm39 C57BL/6J

    Range
    2662471..2663658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)