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Pik3ip1 phosphoinositide-3-kinase interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 216505, updated on 8-Dec-2022

Summary

Official Symbol
Pik3ip1provided by MGI
Official Full Name
phosphoinositide-3-kinase interacting protein 1provided by MGI
Primary source
MGI:MGI:1917016
See related
Ensembl:ENSMUSG00000034614 AllianceGenome:MGI:1917016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crkd; Hgfl; 1500004A08Rik; 5830455E04Rik
Summary
Predicted to enable phosphatidylinositol 3-kinase catalytic subunit binding activity. Involved in negative regulation of phosphatidylinositol 3-kinase activity and negative regulation of phosphatidylinositol 3-kinase signaling. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain meninges; genitourinary system; heart; lung; and oral epithelium. Orthologous to human PIK3IP1 (phosphoinositide-3-kinase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 16.4), testis adult (RPKM 13.6) and 24 other tissues See more
Orthologs
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Genomic context

See Pik3ip1 in Genome Data Viewer
Location:
11; 11 A1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3280731..3292971)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3319241..3342971)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene predicted gene 12592 Neighboring gene predicted gene 11944 Neighboring gene LIM motif-containing protein kinase 2 Neighboring gene predicted gene, 51879 Neighboring gene ring finger protein 185 Neighboring gene RIKEN cDNA 8430429K09 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol 3-kinase catalytic subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol 3-kinase catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphoinositide-3-kinase-interacting protein 1
Names
calcineurin-regulated kringle domain protein
calcineurin-regulated kringle domain-containing protein
kringle domain-containing protein HGFL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178149.4NP_835362.2  phosphoinositide-3-kinase-interacting protein 1 precursor

    See identical proteins and their annotated locations for NP_835362.2

    Status: VALIDATED

    Source sequence(s)
    AI550395, BC079641
    Consensus CDS
    CCDS24357.1
    UniProtKB/Swiss-Prot
    Q7TMJ8, Q811Z3
    Related
    ENSMUSP00000036921.5, ENSMUST00000045153.11
    Conserved Domains (1) summary
    cd00108
    Location:22102
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3280731..3292971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)