Pik3ip1 phosphoinositide-3-kinase interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3ip1provided by MGI
Official Full Name: phosphoinositide-3-kinase interacting protein 1provided by MGI
Primary source: MGI:MGI:1917016
See related: Ensembl:ENSMUSG00000034614 AllianceGenome:MGI:1917016
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crkd; Hgfl; 1500004A08Rik; 5830455E04Rik
Summary: Enables phosphatidylinositol 3-kinase inhibitor activity. Predicted to be involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including brain meninges; genitourinary system; liver; oral epithelium; and spleen. Orthologous to human PIK3IP1 (phosphoinositide-3-kinase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Broad expression in thymus adult (RPKM 16.4), testis adult (RPKM 13.6) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 2.33 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (3280731..3292971)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (3319241..3342971)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of autoimmune disease progression by Pik3ip1 through metabolic reprogramming in T cells and therapeutic implications.
Title: Regulation of autoimmune disease progression by Pik3ip1 through metabolic reprogramming in T cells and therapeutic implications.
PIK3IP1 Promotes Extrafollicular Class Switching in T-Dependent Immune Responses.
Title: PIK3IP1 Promotes Extrafollicular Class Switching in T-Dependent Immune Responses.
Pik3ip1 Is a Negative Immune Regulator that Inhibits Antitumor T-Cell Immunity.
Title: Pik3ip1 Is a Negative Immune Regulator that Inhibits Antitumor T-Cell Immunity.
PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt.
Title: PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt.
Mechanistically, phosphotidyl inositol 3'kinase interacting protein 1 (PIK3IP1), a negative regulator of PI3K, was identified as a novel target of miR-let-7. A conserved hypoxia-responsive Lin28-miR-let-7-Pik3ip1 regulatory axis is specific to cardiac myocytes and promotes apoptosis during myocardial ischemic injury.
Title: A cardiac myocyte-restricted Lin28/let-7 regulatory axis promotes hypoxia-mediated apoptosis by inducing the AKT signaling suppressor PIK3IP1.
Our results identified PIK3IP1 as a novel target of ARID1A and PGR in the murine uterus.
Title: Expression of PIK3IP1 in the murine uterus during early pregnancy.
Pik3ip1 plays a compensatory negative role for physiologic cardiac hypertrophy. Collectively, our results elucidate the mechanisms for the roles of Pik3ip1 in PI3K/AKT signaling pathway
Title: Pik3ip1 modulates cardiac hypertrophy by inhibiting PI3K pathway.
Data suggest that that neural progenitors are particularly vulnerable to FOXO3-induced apoptosis, which is mediated by PIK3IP1, a negative PI3 kinase regulator.
Title: Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors.
PIK3IP1 is an important regulator of PI3K in vivo, and its dysregulation can contribute to liver carcinogenesis
Title: PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (2)
Gene trapped (1)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol 3-kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol 3-kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphoinositide-3-kinase-interacting protein 1

Names: calcineurin-regulated kringle domain protein; calcineurin-regulated kringle domain-containing protein; kringle domain-containing protein HGFL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178149.4 → NP_835362.2 phosphoinositide-3-kinase-interacting protein 1 precursor

See identical proteins and their annotated locations for NP_835362.2

Status: VALIDATED

Source sequence(s)

AI550395, BC079641

Consensus CDS

CCDS24357.1

UniProtKB/Swiss-Prot

Q3TTD5, Q5NBY3, Q5NBY4, Q5NBY6, Q7TMJ8, Q811Z2, Q811Z3

UniProtKB/TrEMBL

Z4YN57

Related

ENSMUSP00000036921.5, ENSMUST00000045153.11

Conserved Domains (1) summary

cd00108
Location:22 → 102

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...