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Pik3ip1 phosphoinositide-3-kinase interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 216505, updated on 21-Apr-2024


Official Symbol
Pik3ip1provided by MGI
Official Full Name
phosphoinositide-3-kinase interacting protein 1provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000034614 AllianceGenome:MGI:1917016
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crkd; Hgfl; 1500004A08Rik; 5830455E04Rik
Predicted to enable phosphatidylinositol 3-kinase catalytic subunit binding activity. Involved in negative regulation of phosphatidylinositol 3-kinase activity and negative regulation of phosphatidylinositol 3-kinase signaling. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain meninges; genitourinary system; heart; lung; and oral epithelium. Orthologous to human PIK3IP1 (phosphoinositide-3-kinase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Broad expression in thymus adult (RPKM 16.4), testis adult (RPKM 13.6) and 24 other tissues See more
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Genomic context

11 A1; 11 2.33 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3280731..3292971)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3319241..3342971)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_28343 Neighboring gene STARR-seq mESC enhancer starr_28345 Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3214183-3214292 Neighboring gene predicted gene 12592 Neighboring gene predicted gene 11944 Neighboring gene STARR-positive B cell enhancer ABC_E5203 Neighboring gene STARR-positive B cell enhancer ABC_E2345 Neighboring gene STARR-positive B cell enhancer ABC_E3929 Neighboring gene STARR-seq mESC enhancer starr_28349 Neighboring gene LIM domain kinase 2 Neighboring gene STARR-seq mESC enhancer starr_28351 Neighboring gene STARR-positive B cell enhancer ABC_E1818 Neighboring gene predicted gene, 51879 Neighboring gene ring finger protein 185 Neighboring gene RIKEN cDNA 8430429K09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3352424-3352533

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

General protein information

Preferred Names
phosphoinositide-3-kinase-interacting protein 1
calcineurin-regulated kringle domain protein
calcineurin-regulated kringle domain-containing protein
kringle domain-containing protein HGFL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178149.4NP_835362.2  phosphoinositide-3-kinase-interacting protein 1 precursor

    See identical proteins and their annotated locations for NP_835362.2

    Status: VALIDATED

    Source sequence(s)
    AI550395, BC079641
    Consensus CDS
    Q3TTD5, Q5NBY3, Q5NBY4, Q5NBY6, Q7TMJ8, Q811Z2, Q811Z3
    ENSMUSP00000036921.5, ENSMUST00000045153.11
    Conserved Domains (1) summary
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000077.7 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)