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Myl6b myosin, light polypeptide 6B [ Mus musculus (house mouse) ]

Gene ID: 216459, updated on 5-Mar-2024

Summary

Official Symbol
Myl6bprovided by MGI
Official Full Name
myosin, light polypeptide 6Bprovided by MGI
Primary source
MGI:MGI:1917789
See related
Ensembl:ENSMUSG00000039824 AllianceGenome:MGI:1917789
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MLC1SA; 5730437E04Rik
Summary
Predicted to enable cytoskeletal motor activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle filament sliding and skeletal muscle tissue development. Predicted to be part of unconventional myosin complex. Is expressed in central nervous system; diaphragm; limb mesenchyme; skeletal musculature; and tail paraxial mesenchyme. Orthologous to human MYL6B (myosin light chain 6B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 7.3), CNS E18 (RPKM 7.2) and 23 other tissues See more
Orthologs
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Genomic context

See Myl6b in Genome Data Viewer
Location:
10 D3; 10 76.77 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128330026..128334554, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128494157..128498685, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E1816 Neighboring gene myosin, light polypeptide 6, alkali, smooth muscle and non-muscle Neighboring gene Riken cDNA A430046D13 gene Neighboring gene STARR-positive B cell enhancer ABC_E8378 Neighboring gene microRNA 6916 Neighboring gene extended synaptotagmin-like protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC41229

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
PubMed 
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of muscle TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in muscle contraction TAS
Traceable Author Statement
more info
PubMed 
involved_in muscle filament sliding TAS
Traceable Author Statement
more info
PubMed 
involved_in skeletal muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of myosin complex TAS
Traceable Author Statement
more info
PubMed 
part_of unconventional myosin complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
myosin light chain 6B
Names
myosin light chain 1 slow a
smooth muscle and nonmuscle myosin light chain alkali 6B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172259.1NP_758463.1  myosin light chain 6B

    See identical proteins and their annotated locations for NP_758463.1

    Status: PROVISIONAL

    Source sequence(s)
    BC037527
    Consensus CDS
    CCDS24279.1
    UniProtKB/Swiss-Prot
    Q8CI43
    Related
    ENSMUSP00000026428.4, ENSMUST00000026428.4
    Conserved Domains (4) summary
    PTZ00184
    Location:57206
    PTZ00184; calmodulin; Provisional
    smart00054
    Location:6795
    EFh; EF-hand, calcium binding motif
    cd00051
    Location:150204
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl08302
    Location:67131
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128330026..128334554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)