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Rxylt1 ribitol xylosyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 216395, updated on 26-Sep-2022

Summary

Official Symbol
Rxylt1provided by MGI
Official Full Name
ribitol xylosyltransferase 1provided by MGI
Primary source
MGI:MGI:2384919
See related
Ensembl:ENSMUSG00000034620 AllianceGenome:MGI:2384919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem5; 6330415D21Rik
Summary
Predicted to enable ribitol beta-1,4-xylosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Located in Golgi apparatus. Is expressed in forelimb bud. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A10. Orthologous to human RXYLT1 (ribitol xylosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 2.7), bladder adult (RPKM 2.0) and 28 other tissues See more
Orthologs
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Genomic context

See Rxylt1 in Genome Data Viewer
Location:
10; 10 D2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (121916844..121933271, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (122080939..122097366, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 48826 Neighboring gene transmembrane emp24 domain trafficking protein 2 pseudogene Neighboring gene predicted gene 4489 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC28135, MGC103359

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ribitol beta-1,4-xylosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribitol beta-1,4-xylosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein O-linked mannosylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ribitol-5-phosphate xylosyltransferase 1
Names
UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase
transmembrane protein 5
NP_001351635.1
NP_694699.1
XP_006513619.1
XP_017169400.1
XP_030100903.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364706.1NP_001351635.1  ribitol-5-phosphate xylosyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158803, AI853079, BC083125, BY124763
    UniProtKB/TrEMBL
    Q8BVJ1
  2. NM_153059.2NP_694699.1  ribitol-5-phosphate xylosyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_694699.1

    Status: VALIDATED

    Source sequence(s)
    AC158803, AK075928, AK078061, BY124763
    Consensus CDS
    CCDS24214.1
    UniProtKB/Swiss-Prot
    Q8R566, Q8VDX6
    Related
    ENSMUSP00000119308.2, ENSMUST00000140299.3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    121916844..121933271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513556.3XP_006513619.1  ribitol-5-phosphate xylosyltransferase 1 isoform X1

  2. XM_030245043.2XP_030100903.1  ribitol-5-phosphate xylosyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    Q8BVJ1
  3. XM_017313911.3XP_017169400.1  ribitol-5-phosphate xylosyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    Q8BVJ1