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Tspan8 tetraspanin 8 [ Mus musculus (house mouse) ]

Gene ID: 216350, updated on 26-Sep-2022

Summary

Official Symbol
Tspan8provided by MGI
Official Full Name
tetraspanin 8provided by MGI
Primary source
MGI:MGI:2384918
See related
Ensembl:ENSMUSG00000034127 AllianceGenome:MGI:2384918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tm4sf3; E330007O21Rik
Summary
Predicted to enable integrin binding activity. Acts upstream of or within regulation of gene expression and spermatogenesis. Located in cell surface. Orthologous to human TSPAN8 (tetraspanin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 83.3), bladder adult (RPKM 27.8) and 10 other tissues See more
Orthologs
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Genomic context

See Tspan8 in Genome Data Viewer
Location:
10; 10 D2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (115652722..115685798)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (115816817..115849893)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930009A15 gene Neighboring gene leucine rich repeat containing G protein coupled receptor 5 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene RIKEN cDNA 4930422I22 gene Neighboring gene protein tyrosine phosphatase, receptor type, R Neighboring gene Taf7l2 Neighboring gene protein tyrosine phosphatase, receptor type, B Neighboring gene predicted gene, 26495

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • MGC38363

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tetraspanin-8
Names
transmembrane 4 superfamily member 3
tspan-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168679.1NP_001162150.1  tetraspanin-8

    See identical proteins and their annotated locations for NP_001162150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC153364, AK077301, DV060937, DV065030
    Consensus CDS
    CCDS24181.1
    UniProtKB/Swiss-Prot
    Q8R3G9
    Related
    ENSMUSP00000136645.2, ENSMUST00000179196.3
    Conserved Domains (1) summary
    pfam00335
    Location:8228
    Tetraspannin; Tetraspanin family
  2. NM_001168680.1NP_001162151.1  tetraspanin-8

    See identical proteins and their annotated locations for NP_001162151.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC153364, AK077301, DV060937
    Consensus CDS
    CCDS24181.1
    UniProtKB/Swiss-Prot
    Q8R3G9
    Related
    ENSMUSP00000079463.4, ENSMUST00000080630.11
    Conserved Domains (1) summary
    pfam00335
    Location:8228
    Tetraspannin; Tetraspanin family
  3. NM_146010.2NP_666122.1  tetraspanin-8

    See identical proteins and their annotated locations for NP_666122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AC126270, AC153364, AK077301, DV060937
    Consensus CDS
    CCDS24181.1
    UniProtKB/Swiss-Prot
    Q8R3G9
    Related
    ENSMUSP00000049243.8, ENSMUST00000035563.15
    Conserved Domains (1) summary
    pfam00335
    Location:8228
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    115652722..115685798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513542.2XP_006513605.1  tetraspanin-8 isoform X1

    See identical proteins and their annotated locations for XP_006513605.1

    UniProtKB/Swiss-Prot
    Q8R3G9
    Conserved Domains (1) summary
    pfam00335
    Location:8228
    Tetraspannin; Tetraspanin family
  2. XM_006513543.5XP_006513606.1  tetraspanin-8 isoform X2

    Conserved Domains (1) summary
    cd03154
    Location:40138
    TM4SF3_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...