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Mettl25 methyltransferase like 25 [ Mus musculus (house mouse) ]

Gene ID: 216292, updated on 6-Jun-2024

Summary

Official Symbol
Mettl25provided by MGI
Official Full Name
methyltransferase like 25provided by MGI
Primary source
MGI:MGI:3041259
See related
Ensembl:ENSMUSG00000036009 AllianceGenome:MGI:3041259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable methyltransferase activity. Predicted to act upstream of or within methylation. Is expressed in adrenal gland; ganglia; telencephalon; and testis. Orthologous to human METTL25 (methyltransferase like 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 2.9), whole brain E14.5 (RPKM 2.4) and 28 other tissues See more
Orthologs
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Genomic context

See Mettl25 in Genome Data Viewer
Location:
10 D1; 10 55.12 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (105599052..105677246, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (105763185..105841380, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene transmembrane and tetratricopeptide repeat containing 2 Neighboring gene keratin 19 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr10:105012433-105012734 Neighboring gene predicted gene 15663 Neighboring gene STARR-seq mESC enhancer starr_27763 Neighboring gene STARR-seq mESC enhancer starr_27765 Neighboring gene STARR-positive B cell enhancer ABC_E9803 Neighboring gene STARR-positive B cell enhancer ABC_E6919 Neighboring gene coiled-coil domain containing 59 Neighboring gene STARR-seq mESC enhancer starr_27766 Neighboring gene STARR-seq mESC enhancer starr_27767 Neighboring gene predicted gene, 25342

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
probable methyltransferase-like protein 25
Names
methyltransferase-like protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359640.1NP_001346569.1  probable methyltransferase-like protein 25 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK148535, AV286383, BB345676, BC067068, CK618051
    Conserved Domains (1) summary
    cl17173
    Location:4268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001359642.1NP_001346571.1  probable methyltransferase-like protein 25 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK148535, AV286383, BC067068, CK618051
    Conserved Domains (1) summary
    cl17173
    Location:4268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_207522.3NP_997405.3  probable methyltransferase-like protein 25 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125108, AC132471
    Consensus CDS
    CCDS36049.2
    UniProtKB/Swiss-Prot
    Q3UMX5, Q6NXH8
    UniProtKB/TrEMBL
    A0A0R4J0G2
    Related
    ENSMUSP00000038665.11, ENSMUST00000046638.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    105599052..105677246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245038.2XP_030100898.1  probable methyltransferase-like protein 25 isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:4268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_030245037.1XP_030100897.1  probable methyltransferase-like protein 25 isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:4268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_017313903.2XP_017169392.1  probable methyltransferase-like protein 25 isoform X3

    UniProtKB/Swiss-Prot
    Q3UMX5, Q6NXH8
    Conserved Domains (1) summary
    cl17173
    Location:149385
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. XM_030245039.1XP_030100899.1  probable methyltransferase-like protein 25 isoform X7

    Conserved Domains (1) summary
    cl17173
    Location:4240
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  5. XM_036155757.1XP_036011650.1  probable methyltransferase-like protein 25 isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:4268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  6. XM_030245031.1XP_030100891.1  probable methyltransferase-like protein 25 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  7. XM_030245033.1XP_030100893.1  probable methyltransferase-like protein 25 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  8. XM_030245032.1XP_030100892.1  probable methyltransferase-like protein 25 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  9. XM_011243412.3XP_011241714.1  probable methyltransferase-like protein 25 isoform X2

    UniProtKB/Swiss-Prot
    Q3UMX5, Q6NXH8
    Conserved Domains (1) summary
    cl17173
    Location:149385
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  10. XM_011243411.3XP_011241713.1  probable methyltransferase-like protein 25 isoform X1

    UniProtKB/Swiss-Prot
    Q3UMX5, Q6NXH8
    Conserved Domains (1) summary
    cl17173
    Location:149413
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  11. XM_011243414.3XP_011241716.1  probable methyltransferase-like protein 25 isoform X4

    See identical proteins and their annotated locations for XP_011241716.1

    Conserved Domains (1) summary
    cl17173
    Location:4268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  12. XM_030245035.1XP_030100895.1  probable methyltransferase-like protein 25 isoform X5

    Conserved Domains (1) summary
    cl17173
    Location:4240
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  13. XM_036155756.1XP_036011649.1  probable methyltransferase-like protein 25 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  14. XM_036155755.1XP_036011648.1  probable methyltransferase-like protein 25 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  15. XM_017313904.1XP_017169393.1  probable methyltransferase-like protein 25 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. XR_004936162.1 RNA Sequence

  2. XR_001779503.2 RNA Sequence

  3. XR_004936161.1 RNA Sequence

    Related
    ENSMUST00000176924.8
  4. XR_003948672.1 RNA Sequence

  5. XR_001779504.2 RNA Sequence

  6. XR_004936163.1 RNA Sequence

  7. XR_004936165.1 RNA Sequence

  8. XR_004936164.1 RNA Sequence

  9. XR_871710.3 RNA Sequence

  10. XR_003948673.1 RNA Sequence

  11. XR_871709.3 RNA Sequence