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Mettl25 methyltransferase like 25 [ Mus musculus (house mouse) ]

Gene ID: 216292, updated on 7-Apr-2025

Summary

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Official Symbol
Mettl25provided by MGI
Official Full Name
methyltransferase like 25provided by MGI
Primary source
MGI:MGI:3041259
See related
Ensembl:ENSMUSG00000036009 AllianceGenome:MGI:3041259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Is expressed in adrenal gland; ganglia; telencephalon; and testis. Orthologous to human METTL25 (methyltransferase like 25). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in CNS E14 (RPKM 2.9), whole brain E14.5 (RPKM 2.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mettl25 in Genome Data Viewer
Location:
10 D1; 10 55.12 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (105599052..105677246, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (105763185..105841380, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene transmembrane and tetratricopeptide repeat containing 2 Neighboring gene keratin 19 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr10:105012433-105012734 Neighboring gene predicted gene 15663 Neighboring gene STARR-seq mESC enhancer starr_27763 Neighboring gene STARR-seq mESC enhancer starr_27765 Neighboring gene STARR-positive B cell enhancer ABC_E9803 Neighboring gene STARR-positive B cell enhancer ABC_E6919 Neighboring gene coiled-coil domain containing 59 Neighboring gene STARR-seq mESC enhancer starr_27766 Neighboring gene STARR-seq mESC enhancer starr_27767 Neighboring gene predicted gene, 25342

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
probable methyltransferase-like protein 25
Names
methyltransferase-like protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359640.1 → NP_001346569.1  probable methyltransferase-like protein 25 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK148535, AV286383, BB345676, BC067068, CK618051
    Conserved Domains (1) summary
    cl17173
    Location:4 → 268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_001359642.1 → NP_001346571.1  probable methyltransferase-like protein 25 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK148535, AV286383, BC067068, CK618051
    Conserved Domains (1) summary
    cl17173
    Location:4 → 268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. NM_207522.3 → NP_997405.3  probable methyltransferase-like protein 25 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125108, AC132471
    Consensus CDS
    CCDS36049.2
    UniProtKB/Swiss-Prot
    Q3UMX5, Q6NXH8
    UniProtKB/TrEMBL
    A0A0R4J0G2
    Related
    ENSMUSP00000038665.11, ENSMUST00000046638.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    105599052..105677246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245038.2 → XP_030100898.1  probable methyltransferase-like protein 25 isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:4 → 268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_030245037.1 → XP_030100897.1  probable methyltransferase-like protein 25 isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:4 → 268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_017313903.2 → XP_017169392.1  probable methyltransferase-like protein 25 isoform X3

    UniProtKB/Swiss-Prot
    Q3UMX5, Q6NXH8
    Conserved Domains (1) summary
    cl17173
    Location:149 → 385
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_030245039.1 → XP_030100899.1  probable methyltransferase-like protein 25 isoform X7

    Conserved Domains (1) summary
    cl17173
    Location:4 → 240
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_036155757.1 → XP_036011650.1  probable methyltransferase-like protein 25 isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:4 → 268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  6. XM_030245031.1 → XP_030100891.1  probable methyltransferase-like protein 25 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4 → 268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  7. XM_030245033.1 → XP_030100893.1  probable methyltransferase-like protein 25 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4 → 268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  8. XM_030245032.1 → XP_030100892.1  probable methyltransferase-like protein 25 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4 → 268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  9. XM_011243412.3 → XP_011241714.1  probable methyltransferase-like protein 25 isoform X2

    UniProtKB/Swiss-Prot
    Q3UMX5, Q6NXH8
    Conserved Domains (1) summary
    cl17173
    Location:149 → 385
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  10. XM_011243411.3 → XP_011241713.1  probable methyltransferase-like protein 25 isoform X1

    UniProtKB/Swiss-Prot
    Q3UMX5, Q6NXH8
    Conserved Domains (1) summary
    cl17173
    Location:149 → 413
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  11. XM_011243414.3 → XP_011241716.1  probable methyltransferase-like protein 25 isoform X4

    See identical proteins and their annotated locations for XP_011241716.1

    Conserved Domains (1) summary
    cl17173
    Location:4 → 268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  12. XM_030245035.1 → XP_030100895.1  probable methyltransferase-like protein 25 isoform X5

    Conserved Domains (1) summary
    cl17173
    Location:4 → 240
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  13. XM_036155756.1 → XP_036011649.1  probable methyltransferase-like protein 25 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4 → 268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  14. XM_036155755.1 → XP_036011648.1  probable methyltransferase-like protein 25 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4 → 268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  15. XM_017313904.1 → XP_017169393.1  probable methyltransferase-like protein 25 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4 → 268
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. XR_004936162.1 RNA Sequence

  2. XR_001779503.2 RNA Sequence

  3. XR_004936161.1 RNA Sequence

    Related
    ENSMUST00000176924.8

  4. XR_003948672.1 RNA Sequence

  5. XR_001779504.2 RNA Sequence

  6. XR_004936163.1 RNA Sequence

  7. XR_004936165.1 RNA Sequence

  8. XR_004936164.1 RNA Sequence

  9. XR_871710.3 RNA Sequence

  10. XR_003948673.1 RNA Sequence

  11. XR_871709.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXH8.1 GenPept UniProtKB/Swiss-Prot:Q6NXH8

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