Slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc17a8provided by MGI
Official Full Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8provided by MGI
Primary source: MGI:MGI:3039629
See related: Ensembl:ENSMUSG00000019935 AllianceGenome:MGI:3039629
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vgt3; Vglut3
Summary: Enables L-glutamate uniporter activity. Involved in L-glutamate transmembrane transport; positive regulation of glutamate uptake involved in transmission of nerve impulse; and regulation of acetylcholine uptake. Located in synaptic vesicle. Is active in glutamatergic synapse and synaptic vesicle membrane. Is expressed in brain; cochlear ganglion; and sensory organ. Used to study autosomal dominant nonsyndromic deafness 25. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to human SLC17A8 (solute carrier family 17 member 8). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 10 C2; 10 44.99 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (89409882..89457111, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (89574020..89621249, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VGLUT3 Deletion Rescues Motor Deficits and Neuronal Loss in the zQ175 Mouse Model of Huntington's Disease.
Title: VGLUT3 Deletion Rescues Motor Deficits and Neuronal Loss in the zQ175 Mouse Model of Huntington's Disease.
Spinal VGLUT3 lineage neurons drive visceral mechanical allodynia but not sensitized visceromotor reflexes.
Title: Spinal VGLUT3 lineage neurons drive visceral mechanical allodynia but not sensitized visceromotor reflexes.
Absence of VGLUT3 Expression Leads to Impaired Fear Memory in Mice.
Title: Absence of VGLUT3 Expression Leads to Impaired Fear Memory in Mice.
VGLUT3 Ablation Differentially Modulates Glutamate Receptor Densities in Mouse Brain.
Title: VGLUT3 Ablation Differentially Modulates Glutamate Receptor Densities in Mouse Brain.
Neurochemically and Hodologically Distinct Ascending VGLUT3 versus Serotonin Subsystems Comprise the r2-Pet1 Median Raphe.
Title: Neurochemically and Hodologically Distinct Ascending VGLUT3 versus Serotonin Subsystems Comprise the r2-Pet1 Median Raphe.
Interrelationships between Cellular Density, Mosaic Patterning, and Dendritic Coverage of VGluT3 Amacrine Cells.
Title: Interrelationships between Cellular Density, Mosaic Patterning, and Dendritic Coverage of VGluT3 Amacrine Cells.
Low-Threshold Mechanosensitive VGLUT3-Lineage Sensory Neurons Mediate Spinal Inhibition of Itch by Touch.
Title: Low-Threshold Mechanosensitive VGLUT3-Lineage Sensory Neurons Mediate Spinal Inhibition of Itch by Touch.
Consequences of VGluT3 deficiency on learning and memory in mice.
Title: Consequences of VGluT3 deficiency on learning and memory in mice.
Spontaneous repair of synapses after noise depends on the level of Vglut3 protein or the level of glutamate release during the recovery period. One copy of the Vglut3 gene is sufficient for noise-induced threshold shift and loss of ribbon synapses, but both copies are required for normal recovery of hearing function and ribbon synapse number.
Title: Vesicular Glutamatergic Transmission in Noise-Induced Loss and Repair of Cochlear Ribbon Synapses.
the expression of VGLUT3 in multiple brain areas is pivotal in gating amphetamine-induced psychomotor adaptations
Title: VGLUT3 gates psychomotor effects induced by amphetamine.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (9) 1 citation

General gene information

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Markers

Slc17a8 (e-PCR), detects polymorphism
- UniSTS:547316

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate uniporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamate uniporter activity	IEA Inferred from Electronic Annotation more info
enables L-glutamate uniporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamate uniporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables chloride channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables neurotransmitter transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:phosphate symporter activity	IEA Inferred from Electronic Annotation more info
enables sodium:phosphate symporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:phosphate symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-glutamate import	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate import	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate import	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
involved_in neural retina development	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter loading into synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter loading into synaptic vesicle	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter loading into synaptic vesicle	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glutamate uptake involved in transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of acetylcholine uptake	IEA Inferred from Electronic Annotation more info
involved_in regulation of acetylcholine uptake	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of acetylcholine uptake	ISO Inferred from Sequence Orthology more info
involved_in regulation of acetylcholine uptake	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synapse structure or activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent phosphate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical dendrite	IEA Inferred from Electronic Annotation more info
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in basal dendrite	IEA Inferred from Electronic Annotation more info
located_in basal dendrite	ISO Inferred from Sequence Orthology more info
located_in clathrin-sculpted glutamate transport vesicle membrane	TAS Traceable Author Statement more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in excitatory synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in excitatory synapse	IEA Inferred from Electronic Annotation more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
located_in glial limiting end-foot	IEA Inferred from Electronic Annotation more info
located_in glial limiting end-foot	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in pericellular basket	IEA Inferred from Electronic Annotation more info
located_in pericellular basket	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in synaptic vesicle membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vesicular glutamate transporter 3

Names: solute carrier family 17 member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310710.1 → NP_001297639.1 vesicular glutamate transporter 3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC127279, AK149687

Consensus CDS

CCDS78880.1

UniProtKB/TrEMBL

D3YTT3

Related

ENSMUSP00000100932.2, ENSMUST00000105295.2

Conserved Domains (1) summary

cd06174
Location:2 → 331

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
NM_182959.3 → NP_892004.1 vesicular glutamate transporter 3 isoform 1

See identical proteins and their annotated locations for NP_892004.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC127279, AF510321

Consensus CDS

CCDS24117.1

UniProtKB/Swiss-Prot

Q8BFU8

Related

ENSMUSP00000020102.8, ENSMUST00000020102.14

Conserved Domains (2) summary

cd06174
Location:93 → 515

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00894
Location:88 → 526

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter