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Slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 [ Mus musculus (house mouse) ]

Gene ID: 216227, updated on 17-Jan-2023

Summary

Official Symbol
Slc17a8provided by MGI
Official Full Name
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8provided by MGI
Primary source
MGI:MGI:3039629
See related
Ensembl:ENSMUSG00000019935 AllianceGenome:MGI:3039629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vglut3
Summary
Enables L-glutamate transmembrane transporter activity. Acts upstream of or within L-glutamate transmembrane transport. Located in synaptic vesicle membrane. Is integral component of synaptic vesicle membrane. Is expressed in brain; cochlear ganglion; and sensory organ. Used to study autosomal dominant nonsyndromic deafness 25. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to human SLC17A8 (solute carrier family 17 member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Slc17a8 in Genome Data Viewer
Location:
10; 10 C2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (89409882..89457111, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (89574020..89621249, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene growth arrest-specific 2 like 3 Neighboring gene nuclear receptor subfamily 1, group H, member 4 Neighboring gene SCY1-like 2 (S. cerevisiae) Neighboring gene RIKEN cDNA 1500026H17 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-glutamate uniporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-glutamate uniporter activity ISO
Inferred from Sequence Orthology
more info
 
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium:phosphate symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-glutamate import ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within L-glutamate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-glutamate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotransmitter loading into synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurotransmitter loading into synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphate ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glutamate uptake involved in transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of acetylcholine uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of acetylcholine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse structure or activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in basal dendrite ISO
Inferred from Sequence Orthology
more info
 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-sculpted glutamate transport vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in excitatory synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in glial limiting end-foot ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in multivesicular body ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in pericellular basket ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
vesicular glutamate transporter 3
Names
solute carrier family 17 member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310710.1NP_001297639.1  vesicular glutamate transporter 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC127279, AK149687
    Consensus CDS
    CCDS78880.1
    UniProtKB/TrEMBL
    D3YTT3, Q3UE85
    Related
    ENSMUSP00000100932.2, ENSMUST00000105295.2
    Conserved Domains (1) summary
    cd06174
    Location:2331
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. NM_182959.3NP_892004.1  vesicular glutamate transporter 3 isoform 1

    See identical proteins and their annotated locations for NP_892004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC127279, AF510321
    Consensus CDS
    CCDS24117.1
    UniProtKB/Swiss-Prot
    Q8BFU8
    Related
    ENSMUSP00000020102.8, ENSMUST00000020102.14
    Conserved Domains (2) summary
    cd06174
    Location:93515
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:88526
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    89409882..89457111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)