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Slc5a8 solute carrier family 5 (iodide transporter), member 8 [ Mus musculus (house mouse) ]

Gene ID: 216225, updated on 5-Aug-2022

Summary

Official Symbol
Slc5a8provided by MGI
Official Full Name
solute carrier family 5 (iodide transporter), member 8provided by MGI
Primary source
MGI:MGI:2384916
See related
Ensembl:ENSMUSG00000020062 AllianceGenome:MGI:2384916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ait; SMCT
Summary
Enables lactate transmembrane transporter activity; monocarboxylate:sodium symporter activity; and propionate transmembrane transporter activity. Acts upstream of or within propanoate transport and short-chain fatty acid import. Predicted to be located in brush border membrane. Is expressed in olfactory epithelium and rectum. Orthologous to human SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 27.7), large intestine adult (RPKM 16.4) and 2 other tissues See more
Orthologs
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Genomic context

See Slc5a8 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (88721854..88765377)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (88885992..88929515)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (88348737..88392260)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 4925 Neighboring gene ADP-ribosylation factor-like 1 Neighboring gene UTP20 small subunit processome component Neighboring gene anoctamin 4 Neighboring gene predicted gene, 30769 Neighboring gene growth arrest-specific 2 like 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC19357

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monocarboxylic acid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in propanoate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within propanoate transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within short-chain fatty acid import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sodium-coupled monocarboxylate transporter 1
Names
electrogenic sodium monocarboxylate cotransporter
solute carrier family 5 member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145423.2NP_663398.2  sodium-coupled monocarboxylate transporter 1

    See identical proteins and their annotated locations for NP_663398.2

    Status: VALIDATED

    Source sequence(s)
    AY484428
    Consensus CDS
    CCDS36026.1
    UniProtKB/Swiss-Prot
    Q8BYF6, Q8VD01
    Related
    ENSMUSP00000020255.7, ENSMUST00000020255.8
    Conserved Domains (1) summary
    cd11519
    Location:7549
    SLC5sbd_SMCT1; Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    88721854..88765377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)