Format

Send to:

Choose Destination

Plk5 polo like kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 216166, updated on 12-Aug-2019

Summary

Official Symbol
Plk5provided by MGI
Official Full Name
polo like kinase 5provided by MGI
Primary source
MGI:MGI:3026984
See related
Ensembl:ENSMUSG00000035486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330514A18Rik
Expression
Biased expression in cerebellum adult (RPKM 19.2), cortex adult (RPKM 4.7) and 6 other tissues See more
Orthologs

Genomic context

See Plk5 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
16
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80356459..80365489)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79819204..79828234)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115487462 Neighboring gene receptor accessory protein 6 Neighboring gene ADAMTS-like 5 Neighboring gene mex3 RNA binding family member D Neighboring gene predicted gene, 30823 Neighboring gene methyl-CpG binding domain protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC106082

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NOT kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
defense response to tumor cell IDA
Inferred from Direct Assay
more info
PubMed 
defense response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
inactive serine/threonine-protein kinase PLK5
Names
PLK-5
plk5
serine/threonine-protein kinase PLK5
NP_001334053.1
NP_898975.2
XP_006513561.1
XP_006513563.1
XP_006513564.1
XP_006513565.1
XP_030100882.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347124.1NP_001334053.1  inactive serine/threonine-protein kinase PLK5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2), has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AC152062, BB622163, BC086684, BE654673, BE985967
    Consensus CDS
    CCDS83729.1
    UniProtKB/Swiss-Prot
    Q4FZD7
    Related
    ENSMUSP00000100988.1, ENSMUST00000105351.1
  2. NM_183152.4NP_898975.2  inactive serine/threonine-protein kinase PLK5 isoform 1

    See identical proteins and their annotated locations for NP_898975.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC152062, BB622163, BC086684, BE654673, BE985967
    Consensus CDS
    CCDS35980.1
    UniProtKB/Swiss-Prot
    Q4FZD7
    UniProtKB/TrEMBL
    G3X967
    Related
    ENSMUSP00000044400.8, ENSMUST00000039836.14
    Conserved Domains (3) summary
    smart00220
    Location:27283
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13118
    Location:414501
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14099
    Location:25283
    STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p6 C57BL/6J

    Range
    80356459..80365489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513498.1XP_006513561.1  inactive serine/threonine-protein kinase PLK5 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:27292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13118
    Location:423510
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14099
    Location:25292
    STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases
  2. XM_006513501.1XP_006513564.1  inactive serine/threonine-protein kinase PLK5 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:27240
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13118
    Location:371458
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cl21453
    Location:25240
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006513500.4XP_006513563.1  inactive serine/threonine-protein kinase PLK5 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:2246
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13118
    Location:377464
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cl21453
    Location:1246
    PKc_like; Protein Kinases, catalytic domain
  4. XM_030245022.1XP_030100882.1  inactive serine/threonine-protein kinase PLK5 isoform X5

  5. XM_006513502.3XP_006513565.1  inactive serine/threonine-protein kinase PLK5 isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:4225
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13118
    Location:356443
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cl21453
    Location:5225
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_380383.1 RNA Sequence

Support Center