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Med16 mediator complex subunit 16 [ Mus musculus (house mouse) ]

Gene ID: 216154, updated on 23-Jun-2021

Summary

Official Symbol
Med16provided by MGI
Official Full Name
mediator complex subunit 16provided by MGI
Primary source
MGI:MGI:2158394
See related
Ensembl:ENSMUSG00000013833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Thr; Tra; 95kD; 95kDa; DRIP92; Thrap5; Trap95; A630083L04
Expression
Ubiquitous expression in testis adult (RPKM 63.2), ovary adult (RPKM 52.5) and 28 other tissues See more
Orthologs
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Genomic context

See Med16 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79730540..79744772, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79894706..79908938, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79357452..79371683, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S21 pseudogene Neighboring gene complement factor D (adipsin) Neighboring gene predicted gene, 24019 Neighboring gene R3H domain containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 16
Names
thyroid hormone receptor associated protein 5
thyroid hormone receptor-associated protein complex 95 kDa component
thyroid hormone receptor-associated protein, 95-kD subunit
vitamin D3 receptor-interacting protein complex 92 kDa component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163276.1NP_001156748.1  mediator of RNA polymerase II transcription subunit 16 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter by 1 aa when it is compared to isoform 1.
    Source sequence(s)
    AK149345, BB731333, BY019373, BY480428
    Consensus CDS
    CCDS48623.1
    UniProtKB/TrEMBL
    E9QP84, Q3UET8
    Related
    ENSMUSP00000101017.3, ENSMUST00000105378.9
    Conserved Domains (4) summary
    smart00320
    Location:94133
    WD40; WD40 repeats
    COG2319
    Location:84279
    WD40; WD40 repeat [General function prediction only]
    pfam11635
    Location:143857
    Med16; Mediator complex subunit 16
    sd00039
    Location:61103
    7WD40; WD40 repeat [structural motif]
  2. NM_001359629.1NP_001346558.1  mediator of RNA polymerase II transcription subunit 16 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 3), has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC151846, AK042340, BC057056, BY133011, CR520085
    Conserved Domains (3) summary
    smart00320
    Location:95134
    WD40; WD40 repeats
    sd00039
    Location:62104
    7WD40; WD40 repeat [structural motif]
    pfam11635
    Location:144737
    Med16; Mediator complex subunit 16
  3. NM_198107.2NP_932775.2  mediator of RNA polymerase II transcription subunit 16 isoform 1

    See identical proteins and their annotated locations for NP_932775.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AK042340, AK149345, BB731333, BY019373, DT908554
    Consensus CDS
    CCDS23996.2
    UniProtKB/TrEMBL
    G3UW74, Q3UET8
    Related
    ENSMUSP00000129375.2, ENSMUST00000165684.8
    Conserved Domains (4) summary
    smart00320
    Location:95134
    WD40; WD40 repeats
    COG2319
    Location:85280
    WD40; WD40 repeat [General function prediction only]
    pfam11635
    Location:144858
    Med16; Mediator complex subunit 16
    sd00039
    Location:62104
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79730540..79744772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513487.5XP_006513550.1  mediator of RNA polymerase II transcription subunit 16 isoform X1

    See identical proteins and their annotated locations for XP_006513550.1

    Conserved Domains (3) summary
    smart00320
    Location:5998
    WD40; WD40 repeats
    sd00039
    Location:2668
    7WD40; WD40 repeat [structural motif]
    pfam11635
    Location:108822
    Med16; Mediator complex subunit 16
  2. XM_036155735.1XP_036011628.1  mediator of RNA polymerase II transcription subunit 16 isoform X1

    Conserved Domains (3) summary
    smart00320
    Location:5998
    WD40; WD40 repeats
    sd00039
    Location:2668
    7WD40; WD40 repeat [structural motif]
    pfam11635
    Location:108822
    Med16; Mediator complex subunit 16
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