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Mcu mitochondrial calcium uniporter [ Mus musculus (house mouse) ]

Gene ID: 215999, updated on 27-May-2024

Summary

Official Symbol
Mcuprovided by MGI
Official Full Name
mitochondrial calcium uniporterprovided by MGI
Primary source
MGI:MGI:3026965
See related
Ensembl:ENSMUSG00000009647 AllianceGenome:MGI:3026965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm64; C10orf42; Ccdc109a; 2010012O16Rik; D130073L02Rik
Summary
Predicted to enable calcium channel activity; identical protein binding activity; and uniporter activity. Involved in mitochondrial calcium ion transmembrane transport and positive regulation of mitochondrial calcium ion concentration. Located in mitochondrion. Part of calcium channel complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and vertebral axis musculature. Orthologous to human MCU (mitochondrial calcium uniporter). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 29.1), bladder adult (RPKM 21.1) and 28 other tissues See more
Orthologs
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Genomic context

See Mcu in Genome Data Viewer
Location:
10 B4; 10 29.55 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (59282806..59453231, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (59446984..59617409, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group XIIB Neighboring gene oncoprotein induced transcript 3 Neighboring gene predicted gene, 36318 Neighboring gene STARR-seq mESC enhancer starr_26771 Neighboring gene STARR-seq mESC enhancer starr_26772 Neighboring gene predicted gene, 40671 Neighboring gene STARR-positive B cell enhancer ABC_E9788 Neighboring gene predicted gene 10322 Neighboring gene STARR-seq mESC enhancer starr_26775 Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene predicted gene, 40672

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables uniporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables uniporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in calcium import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within calcium import into the mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in calcium import into the mitochondrion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of uniplex complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of uniplex complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcium uniporter protein, mitochondrial
Names
coiled-coil domain containing 109A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033259.4NP_001028431.2  calcium uniporter protein, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001028431.2

    Status: VALIDATED

    Source sequence(s)
    AC022699, AK144727, AK161322
    Consensus CDS
    CCDS23866.2
    UniProtKB/Swiss-Prot
    B2RTD1, Q3TTK3, Q3UMR5
    Related
    ENSMUSP00000020312.7, ENSMUST00000020312.13
    Conserved Domains (1) summary
    pfam04678
    Location:116319
    MCU; Mitochondrial calcium uniporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    59282806..59453231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245012.1XP_030100872.1  calcium uniporter protein, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam04678
    Location:77279
    MCU; Mitochondrial calcium uniporter
  2. XM_006513468.2XP_006513531.1  calcium uniporter protein, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam04678
    Location:77279
    MCU; Mitochondrial calcium uniporter