Adgb androglobin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adgbprovided by MGI
Official Full Name: androglobinprovided by MGI
Primary source: MGI:MGI:3605549
See related: Ensembl:ENSMUSG00000050994 AllianceGenome:MGI:3605549
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9130014G24Rik
Summary: Predicted to enable calcium-dependent cysteine-type endopeptidase activity; heme binding activity; and oxygen binding activity. Predicted to be involved in proteolysis. Is expressed in lung. Orthologous to human ADGB (androglobin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 5.3), liver E18 (RPKM 0.6) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10; 10 A1

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (10211447..10350837, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (10335703..10475093, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

D10Mit312 (e-PCR), detects polymorphism
- UniSTS:126212

NoName (e-PCR)
- UniSTS:493288

Homology

Homologs of the Adgb gene: The Adgb gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 485 organisms have orthologs with human gene Adgb
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-dependent cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in sperm annulus	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: androglobin

Names: calpain-7-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127353.4 → NP_001120825.3 androglobin

Status: VALIDATED

Source sequence(s)

AC153567, AC159380

Related

ENSMUSP00000136386.2, ENSMUST00000179956.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

10211447..10350837 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243163.3 → XP_011241465.1 androglobin isoform X5

Conserved Domains (2) summary

PTZ00121
Location:1284 → 1651

PTZ00121; MAEBL; Provisional

cl00051
Location:200 → 307

CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
XM_017313876.2 → XP_017169365.1 androglobin isoform X4

Conserved Domains (2) summary

PTZ00121
Location:1310 → 1677

PTZ00121; MAEBL; Provisional

cl00051
Location:200 → 307

CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
XM_030244999.1 → XP_030100859.1 androglobin isoform X7

Conserved Domains (2) summary

pfam09731
Location:1329 → 1639

Mitofilin; Mitochondrial inner membrane protein

cl00051
Location:200 → 307

CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
XM_011243160.3 → XP_011241462.1 androglobin isoform X2

Conserved Domains (2) summary

PTZ00121
Location:1328 → 1695

PTZ00121; MAEBL; Provisional

cl00051
Location:200 → 307

CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
XM_017313877.2 → XP_017169366.1 androglobin isoform X6

Conserved Domains (2) summary

PTZ00121
Location:1332 → 1640

PTZ00121; MAEBL; Provisional

cl00051
Location:200 → 307

CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
XM_017313875.2 → XP_017169364.1 androglobin isoform X1

Conserved Domains (2) summary

PTZ00121
Location:1329 → 1696

PTZ00121; MAEBL; Provisional

cl00051
Location:200 → 307

CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
XM_017313879.3 → XP_017169368.1 androglobin isoform X10

Related

ENSMUSP00000134378.2, ENSMUST00000172530.8

Conserved Domains (2) summary

PTZ00121
Location:1296 → 1663

PTZ00121; MAEBL; Provisional

cl00051
Location:186 → 293

CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
XM_006512658.5 → XP_006512721.1 androglobin isoform X3

Conserved Domains (2) summary

PTZ00121
Location:1315 → 1682

PTZ00121; MAEBL; Provisional

cl00051
Location:186 → 293

CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
XM_006512663.4 → XP_006512726.1 androglobin isoform X8

Conserved Domains (1) summary

PTZ00121
Location:896 → 1263

PTZ00121; MAEBL; Provisional
XM_017313878.2 → XP_017169367.1 androglobin isoform X9

Conserved Domains (1) summary

cl00051
Location:200 → 307

CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.