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Tcrb T cell receptor beta chain [ Mus musculus (house mouse) ]

Gene ID: 21577, updated on 24-Aug-2021

Summary

Official Symbol
Tcrbprovided by MGI
Official Full Name
T cell receptor beta chainprovided by MGI
Primary source
MGI:MGI:98578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ti; Tib; TCRbe; TCRbeta
Summary
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes several trypsinogen genes. [provided by RefSeq, Jul 2008]
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Genomic context

See Tcrb in Genome Data Viewer
Location:
6 B1; 6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40868230..41535305)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40891296..41558371)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (40841295..41508370)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene maltase-glucoamylase 2, pseudogene Neighboring gene RIKEN cDNA 1810009J06 gene Neighboring gene monooxygenase, DBH-like 2 Neighboring gene protease, serine 58 Neighboring gene T cell receptor beta, variable 1 Neighboring gene protease, serine 59 Neighboring gene trypsinogen pseudogene Neighboring gene RIKEN cDNA 2210010C04 gene Neighboring gene predicted gene 2663 Neighboring gene T cell receptor beta, variable 2 Neighboring gene T cell receptor beta, variable 3 Neighboring gene T cell receptor beta, variable 10 Neighboring gene T cell receptor beta, variable 5 Neighboring gene T cell receptor beta variable 6 Neighboring gene T cell receptor beta variable 7 Neighboring gene T cell receptor beta, variable 12-1 Neighboring gene T cell receptor beta variable 10 Neighboring gene T cell receptor beta, variable 13-1 Neighboring gene T cell receptor beta variable 8 Neighboring gene T cell receptor beta, variable 12-2 Neighboring gene T cell receptor beta, variable 13-2 Neighboring gene T cell receptor beta variable 9 Neighboring gene T cell receptor beta, variable 12-3 Neighboring gene T cell receptor beta, variable 13-3 Neighboring gene T cell receptor beta variable 11 Neighboring gene T cell receptor beta, variable 14 Neighboring gene T cell receptor beta, variable 15 Neighboring gene T cell receptor beta, variable 16 Neighboring gene T cell receptor beta, variable 17 Neighboring gene T cell receptor beta variable 18 Neighboring gene T cell receptor beta, variable 19 Neighboring gene T cell receptor beta, variable 20 Neighboring gene T cell receptor beta, variable 21 Neighboring gene T cell receptor beta variable 22 Neighboring gene T cell receptor beta, variable V23 Neighboring gene T cell receptor beta, variable 24 Neighboring gene T cell receptor beta variable 25 Neighboring gene T cell receptor beta, variable 26 Neighboring gene protein tyrosine phosphatase domain containing 1 pseudogene Neighboring gene T cell receptor beta variable 27 Neighboring gene T cell receptor beta variable 28 Neighboring gene T cell receptor beta, variable 29 Neighboring gene T cell receptor beta, variable 30 Neighboring gene cell division cycle 42 homolog pseudogene Neighboring gene trypsin 4 Neighboring gene trypsin 5 Neighboring gene trypsin 10 Neighboring gene protease, serine 3 Neighboring gene predicted gene 5771 Neighboring gene Try10-like trypsinogen pseudogene Neighboring gene predicted gene 10334 Neighboring gene protease, serine 1 (trypsin 1) Neighboring gene proline-rich polypeptide 3 pseudogene Neighboring gene T cell receptor beta joining 1-3 Neighboring gene T cell receptor beta joining 1-2 Neighboring gene T cell receptor beta joining 1-1 Neighboring gene T cell receptor beta joining 1-4 Neighboring gene T cell receptor beta joining 1-5 Neighboring gene T cell receptor beta joining 1-6 Neighboring gene T cell receptor beta joining 1-7 Neighboring gene T cell receptor beta joining 2-6 Neighboring gene T cell receptor beta joining 2-1 Neighboring gene T cell receptor beta joining 2-2 Neighboring gene T cell receptor beta joining 2-3 Neighboring gene T cell receptor beta joining 2-4 Neighboring gene T cell receptor beta joining 2-5 Neighboring gene protease, serine 2 Neighboring gene T cell receptor beta joining 2-7 Neighboring gene T cell receptor beta, D region 1 Neighboring gene T cell receptor beta, constant region 1 Neighboring gene T cell receptor beta, D region 2 Neighboring gene T cell receptor beta, constant 2 Neighboring gene T cell receptor beta, variable 31 Neighboring gene predicted gene, 27549 Neighboring gene Eph receptor B6

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_006980.1 

    Range
    502..667577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    40868230..41535305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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