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Miga1 mitoguardin 1 [ Mus musculus (house mouse) ]

Gene ID: 215708, updated on 12-May-2024

Summary

Official Symbol
Miga1provided by MGI
Official Full Name
mitoguardin 1provided by MGI
Primary source
MGI:MGI:1924567
See related
Ensembl:ENSMUSG00000054942 AllianceGenome:MGI:1924567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mita1; Fam73a; A930038D06; C030011O14Rik
Summary
Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Predicted to be located in mitochondrion. Predicted to be integral component of plasma membrane. Is expressed in brain; metanephros; spinal cord; and testis. Orthologous to human MIGA1 (mitoguardin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 11.0), cortex adult (RPKM 9.9) and 25 other tissues See more
Orthologs
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Genomic context

See Miga1 in Genome Data Viewer
Location:
3 H3; 3 77.1 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (151979096..152046073, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152273459..152340436, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:151922476-151922776 Neighboring gene nexilin Neighboring gene predicted gene, 31999 Neighboring gene VISTA enhancer mm72 Neighboring gene ubiquitin specific peptidase 33 Neighboring gene zinc finger, ZZ domain containing 3 Neighboring gene predicted gene, 57837

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5)  1 citation
  • Targeted (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitoguardin 1
Names
family with sequence similarity 73, member A
protein FAM73A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162375.1NP_001155847.1  mitoguardin 1 isoform 2

    See identical proteins and their annotated locations for NP_001155847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons in the coding region compared to variant 1. The encoded isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC123075, AK045347, AK085017
    Consensus CDS
    CCDS51096.1
    UniProtKB/Swiss-Prot
    Q4QQM5
    Related
    ENSMUSP00000068261.7, ENSMUST00000068243.11
    Conserved Domains (1) summary
    pfam10265
    Location:27507
    DUF2217; Uncharacterized conserved protein (DUF2217)
  2. NM_174868.4NP_777357.2  mitoguardin 1 isoform 1

    See identical proteins and their annotated locations for NP_777357.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC123075, AK085017, BC098205
    Consensus CDS
    CCDS17916.1
    UniProtKB/Swiss-Prot
    Q4QQM5, Q8BR91, Q8C3S6, Q8C8P4
    UniProtKB/TrEMBL
    B2RRB9
    Related
    ENSMUSP00000072836.7, ENSMUST00000073089.13
    Conserved Domains (1) summary
    pfam10265
    Location:27571
    DUF2217; Uncharacterized conserved protein (DUF2217)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    151979096..152046073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163015.1XP_036018908.1  mitoguardin 1 isoform X3

    Conserved Domains (1) summary
    pfam10265
    Location:2306
    Miga; Mitoguardin
  2. XM_011240070.4XP_011238372.1  mitoguardin 1 isoform X1

    Related
    ENSMUSP00000143238.2, ENSMUST00000199334.5
    Conserved Domains (1) summary
    pfam10265
    Location:27489
    Miga; Mitoguardin
  3. XM_036163016.1XP_036018909.1  mitoguardin 1 isoform X4

    Conserved Domains (1) summary
    pfam10265
    Location:27301
    Miga; Mitoguardin
  4. XM_036163014.1XP_036018907.1  mitoguardin 1 isoform X2

    Conserved Domains (1) summary
    pfam10265
    Location:27339
    Miga; Mitoguardin

RNA

  1. XR_001783676.2 RNA Sequence