Mageb18 MAGE family member B18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mageb18provided by MGI
Official Full Name: MAGE family member B18provided by MGI
Primary source: MGI:MGI:3045344
See related: Ensembl:ENSMUSG00000067649 AllianceGenome:MGI:3045344
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B430216B18Rik
Summary: Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in several structures, including brain; egg cylinder; gonad; heart; and liver. Orthologous to human MAGEB18 (MAGE family member B18). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: X; X C2- C3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (91162485..91643178, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (92118879..92599572, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

demonstrate that knockdown of MAGEB18 inhibits the growth of B16-F0 cells and induces apoptosis, which correlates with increased levels of TP53 (tumour protein 53), p21, Bax and caspase 3
Title: The mouse Mageb18 gene encodes a ubiquitously expressed type I MAGE protein and regulates cell proliferation and apoptosis in melanoma B16-F0 cells.

Submit: New GeneRIF Correction

General gene information

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Markers

px-19c6 (e-PCR)
- UniSTS:257371

Bsg (e-PCR), detects polymorphism
- UniSTS:265615

NoName (e-PCR)
- UniSTS:492746

px-27g1 (e-PCR)
- UniSTS:257504

px-60d9 (e-PCR)
- UniSTS:258017

px-61e2 (e-PCR)
- UniSTS:258040

px-61f4 (e-PCR)
- UniSTS:258045

Homology

Homologs of the Mageb18 gene: The Mageb18 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: melanoma-associated antigen B18

Names: MAGE-B18 antigen; melanoma antigen family B, 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173783.3 → NP_776144.1 melanoma-associated antigen B18

See identical proteins and their annotated locations for NP_776144.1

Status: VALIDATED

Source sequence(s)

AK046641

Consensus CDS

CCDS30268.1

UniProtKB/Swiss-Prot

Q8BQR7

Related

ENSMUSP00000109588.2, ENSMUST00000113955.2

Conserved Domains (2) summary

pfam01454
Location:98 → 265

MAGE; MAGE family

pfam12440
Location:5 → 77

MAGE_N; Melanoma associated antigen family N terminal