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Rap1b RAS related protein 1b [ Mus musculus (house mouse) ]

Gene ID: 215449, updated on 21-Apr-2024

Summary

Official Symbol
Rap1bprovided by MGI
Official Full Name
RAS related protein 1bprovided by MGI
Primary source
MGI:MGI:894315
See related
Ensembl:ENSMUSG00000052681 AllianceGenome:MGI:894315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810443E11Rik
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within several processes, including negative regulation of regulated secretory pathway; positive regulation of ERK1 and ERK2 cascade; and small GTPase mediated signal transduction. Predicted to be located in cell-cell junction; cytosol; and lipid droplet. Predicted to be active in plasma membrane. Is expressed in brain and cerebral cortex. Orthologous to human RAP1B (RAP1B, member of RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 61.6), bladder adult (RPKM 57.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
10 D2; 10 66.32 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (117650502..117681879, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117814597..117845974, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member E3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:117192156-117192497 Neighboring gene nucleoporin 107 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:117229949-117230058 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:117235617-117235851 Neighboring gene STARR-seq mESC enhancer starr_28002 Neighboring gene STARR-positive B cell enhancer ABC_E10647 Neighboring gene STARR-positive B cell enhancer mm9_chr10:117273422-117273722 Neighboring gene STARR-positive B cell enhancer ABC_E9807 Neighboring gene predicted gene, 53637 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:117298174-117298357 Neighboring gene predicted gene, 40773 Neighboring gene predicted gene, 32552 Neighboring gene predicted gene, 32605 Neighboring gene STARR-positive B cell enhancer mm9_chr10:117346931-117347231 Neighboring gene STARR-positive B cell enhancer mm9_chr10:117347418-117347719

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in Rap protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of calcium-ion regulated exocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in cellular response to cAMP IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of establishment of localization in cell IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in modification of postsynaptic structure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modification of postsynaptic structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of calcium ion-dependent exocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of synaptic vesicle exocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within small GTPase-mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ras-related protein Rap-1b
Names
GTP-binding protein smg p21B
NP_077777.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024457.2NP_077777.1  ras-related protein Rap-1b

    See identical proteins and their annotated locations for NP_077777.1

    Status: VALIDATED

    Source sequence(s)
    AK180095, BU848028, BY369341, CK793274, CO803632
    Consensus CDS
    CCDS24196.1
    UniProtKB/Swiss-Prot
    Q99JI6
    UniProtKB/TrEMBL
    Q3V3W9, Q52L50
    Related
    ENSMUSP00000066238.8, ENSMUST00000064667.9
    Conserved Domains (1) summary
    cd04175
    Location:3167
    Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    117650502..117681879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)