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Hip1 huntingtin interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 215114, updated on 3-Jun-2018
Official Symbol
Hip1provided by MGI
Official Full Name
huntingtin interacting protein 1provided by MGI
Primary source
MGI:MGI:1099804
See related
Ensembl:ENSMUSG00000039959 Vega:OTTMUSG00000055920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4113; 2610109B09Rik; A930014B11Rik; E130315I21Rik
Expression
Ubiquitous expression in lung adult (RPKM 13.0), subcutaneous fat pad adult (RPKM 12.6) and 27 other tissues See more
Orthologs
See Hip1 in Genome Data Viewer
Location:
5 G2; 5 75.18 cM
Exon count:
35
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (135406518..135545320, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (135882388..136020992, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene NOL1/NOP2/Sun domain family, member 5 Neighboring gene nuclear pore membrane protein 121 Neighboring gene microRNA 7033 Neighboring gene chemokine (C-C motif) ligand 26 Neighboring gene chemokine (C-C motif) ligand 24

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4113, MGC27616

Gene Ontology Provided by MGI

Function Evidence Code Pubs
AP-2 adaptor complex binding ISO
Inferred from Sequence Orthology
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin light chain binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
 
endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
COLOCALIZES_WITH AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COLOCALIZES_WITH clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
COLOCALIZES_WITH cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
postsynapse ISO
Inferred from Sequence Orthology
more info
 
presynapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynapse ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
huntingtin-interacting protein 1
Names
HIP-I
hip1
huntingtin-interacting protein I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146001.2NP_666113.2  huntingtin-interacting protein 1

    See identical proteins and their annotated locations for NP_666113.2

    Status: VALIDATED

    Source sequence(s)
    AK147246, BC017516, BY309818, CF746398
    Consensus CDS
    CCDS51663.1
    UniProtKB/Swiss-Prot
    Q8VD75
    Related
    ENSMUSP00000059033.8, OTTMUSP00000072737, ENSMUST00000060311.11, OTTMUST00000138327
    Conserved Domains (5) summary
    smart00307
    Location:8061004
    ILWEQ; I/LWEQ domain
    pfam05010
    Location:445610
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam07651
    Location:37308
    ANTH; ANTH domain
    pfam14335
    Location:336441
    DUF4391; Domain of unknown function (DUF4391)
    pfam16515
    Location:482572
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    135406518..135545320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240878.2XP_011239180.1  huntingtin-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011239180.1

    UniProtKB/Swiss-Prot
    Q8VD75
    Conserved Domains (5) summary
    smart00307
    Location:8061004
    ILWEQ; I/LWEQ domain
    pfam05010
    Location:445610
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam07651
    Location:37308
    ANTH; ANTH domain
    pfam14335
    Location:336441
    DUF4391; Domain of unknown function (DUF4391)
    pfam16515
    Location:482572
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  2. XM_011240879.2XP_011239181.1  huntingtin-interacting protein 1 isoform X2

    Conserved Domains (5) summary
    smart00307
    Location:781979
    ILWEQ; I/LWEQ domain
    pfam05010
    Location:420585
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam07651
    Location:15283
    ANTH; ANTH domain
    pfam14335
    Location:311416
    DUF4391; Domain of unknown function (DUF4391)
    pfam16515
    Location:457547
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  3. XM_006504415.3XP_006504478.1  huntingtin-interacting protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006504478.1

    Conserved Domains (5) summary
    smart00307
    Location:772970
    ILWEQ; I/LWEQ domain
    pfam05010
    Location:411576
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam07651
    Location:7274
    ANTH; ANTH domain
    pfam14335
    Location:302407
    DUF4391; Domain of unknown function (DUF4391)
    pfam16515
    Location:448538
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

RNA

  1. XR_868560.2 RNA Sequence

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