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F2RL2 coagulation factor II thrombin receptor like 2 [ Homo sapiens (human) ]

Gene ID: 2151, updated on 22-Aug-2020

Summary

Official Symbol
F2RL2provided by HGNC
Official Full Name
coagulation factor II thrombin receptor like 2provided by HGNC
Primary source
HGNC:HGNC:3539
See related
Ensembl:ENSG00000164220 MIM:601919
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAR3; PAR-3
Summary
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]
Expression
Biased expression in gall bladder (RPKM 4.3), endometrium (RPKM 1.5) and 10 other tissues See more
Orthologs

Genomic context

See F2RL2 in Genome Data Viewer
Location:
5q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (76615482..76623403, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (75911307..75919259, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 2 Neighboring gene sulfiredoxin 1 pseudogene Neighboring gene uncharacterized LOC101929109 Neighboring gene non-protein coding RNA, upstream of F2R/PAR1 Neighboring gene coagulation factor II thrombin receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study for age-related hearing impairment in the Saami.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of coagulation factor II (thrombin) receptor-like 2 (F2RL2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ51933

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol phospholipase C activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thrombin-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteinase-activated receptor 3
Names
Coagulation factor II receptor-like 2 (protease-actovated receptor 3)
protease-activated receptor 3
thrombin receptor-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256566.2NP_001243495.1  proteinase-activated receptor 3 isoform 2

    See identical proteins and their annotated locations for NP_001243495.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC026725, AK298585, AL048674
    Consensus CDS
    CCDS58959.1
    UniProtKB/Swiss-Prot
    O00254
    Related
    ENSP00000426703.1, ENST00000504899.1
    Conserved Domains (1) summary
    cd15371
    Location:73346
    7tmA_PAR3; protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_004101.4NP_004092.1  proteinase-activated receptor 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_004092.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC026725, AL048674, BC093650, DC419029
    Consensus CDS
    CCDS4031.1
    UniProtKB/Swiss-Prot
    O00254
    Related
    ENSP00000296641.3, ENST00000296641.5
    Conserved Domains (1) summary
    cd15371
    Location:95368
    7tmA_PAR3; protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    76615482..76623403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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