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Wfikkn1 WAP, FS, Ig, KU, and NTR-containing protein 1 [ Mus musculus (house mouse) ]

Gene ID: 215001, updated on 18-Apr-2024

Summary

Official Symbol
Wfikkn1provided by MGI
Official Full Name
WAP, FS, Ig, KU, and NTR-containing protein 1provided by MGI
Primary source
MGI:MGI:2670967
See related
Ensembl:ENSMUSG00000071192 AllianceGenome:MGI:2670967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gasp2; Wfikkn
Summary
Predicted to enable receptor antagonist activity and transforming growth factor beta binding activity. Acts upstream of or within several processes, including muscle cell development; negative regulation of DNA binding activity; and roof of mouth development. Located in extracellular region. Orthologous to human WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 1.5), stomach adult (RPKM 1.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
17 A3.3; 17 12.97 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26096602..26099832, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25877628..25880858, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10938 Neighboring gene nuclear encoded tRNA glycine 7 (anticodon CCC) Neighboring gene methyltransferase like 26 Neighboring gene Rab40C, member RAS oncogene family Neighboring gene cytochrome c oxidase subunit 7C, pseudogene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:26056925-26057108 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Q Neighboring gene NHL repeat containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
Names
GASP-2
growth and differentiation factor-associated serum protein 2
mGASP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100454.1NP_001093924.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_001093924.1

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Consensus CDS
    CCDS50038.1
    UniProtKB/Swiss-Prot
    Q8R0S6
    UniProtKB/TrEMBL
    A0A498WFR4
    Related
    ENSMUSP00000135083.3, ENSMUST00000176696.3
    Conserved Domains (7) summary
    cd05765
    Location:204284
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    smart00131
    Location:361413
    KU; BPTI/Kunitz family of serine protease inhibitors
    cd00104
    Location:124161
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:196284
    I-set; Immunoglobulin I-set domain
    pfam00095
    Location:3480
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    cl00101
    Location:311356
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cl02512
    Location:431541
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26096602..26099832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)