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F2R coagulation factor II thrombin receptor [ Homo sapiens (human) ]

Gene ID: 2149, updated on 22-Aug-2020

Summary

Official Symbol
F2Rprovided by HGNC
Official Full Name
coagulation factor II thrombin receptorprovided by HGNC
Primary source
HGNC:HGNC:3537
See related
Ensembl:ENSG00000181104 MIM:187930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR; HTR; CF2R; PAR1; PAR-1
Summary
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in spleen (RPKM 37.1), gall bladder (RPKM 26.8) and 21 other tissues See more
Orthologs

Genomic context

See F2R in Genome Data Viewer
Location:
5q13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (76716126..76735770)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76011868..76031595)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 2 Neighboring gene coagulation factor II thrombin receptor like 2 Neighboring gene non-protein coding RNA, upstream of F2R/PAR1 Neighboring gene RNA, 7SL, cytoplasmic 208, pseudogene Neighboring gene F2R like trypsin receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
New gene functions in megakaryopoiesis and platelet formation.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infectivity is decreased by F2R (PAR1), but not F2R (PAR1) mutant R46A, overexpression in the virus producing cells (HEK293T) PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 (HXBC2) gp160 furin-mediated processing is inhibited by F2R (PAR1) whilst F2R (PAR1) K46A does not (in COS-1 and HEK293T cells), indicating amino acid residue F2R Arg46 as critical for the inhibitory effect PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp160 furin-mediated processing to gp41 is inhibited by PAR1 in cells (COS-1 and HEK293T) overexpressing F2R PubMed
Vpr vpr F2R (PAR1) DOES NOT block processing of Vpr by soluble PCSK6 (PACE4) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
G-protein alpha-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
G-protein beta-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
thrombin-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thrombin-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of MAPKK activity ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
cell-cell junction maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
connective tissue replacement involved in inflammatory response wound healing IDA
Inferred from Direct Assay
more info
PubMed 
establishment of synaptic specificity at neuromuscular junction ISS
Inferred from Sequence or Structural Similarity
more info
 
homeostasis of number of cells within a tissue ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glomerular filtration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of renin secretion into blood stream ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
platelet dense granule organization IC
Inferred by Curator
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of JAK-STAT cascade NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of collagen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vasoconstriction ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interleukin-1 beta production ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
release of sequestered calcium ion into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
thrombin-activated receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet dense tubular network IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proteinase-activated receptor 1
Names
protease-activated receptor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032906.1 RefSeqGene

    Range
    5084..24728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001311313.2NP_001298242.1  proteinase-activated receptor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK308169, BC051909, BM994328, DA799420
    UniProtKB/Swiss-Prot
    P25116
    Conserved Domains (1) summary
    pfam00001
    Location:1250
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001992.5NP_001983.2  proteinase-activated receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001983.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC051909, BM994328
    Consensus CDS
    CCDS4032.1
    UniProtKB/Swiss-Prot
    P25116
    UniProtKB/TrEMBL
    A0A024RAP7
    Related
    ENSP00000321326.4, ENST00000319211.5
    Conserved Domains (1) summary
    pfam00001
    Location:120371
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    76716126..76735770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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