U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Syde2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) [ Mus musculus (house mouse) ]

Gene ID: 214804, updated on 26-Sep-2022

Summary

Official Symbol
Syde2provided by MGI
Official Full Name
synapse defective 1, Rho GTPase, homolog 2 (C. elegans)provided by MGI
Primary source
MGI:MGI:3036264
See related
Ensembl:ENSMUSG00000036863 AllianceGenome:MGI:3036264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C430017H16Rik
Summary
Predicted to act upstream of or within cell migration. Is expressed in spongiotrophoblast and trophectoderm. Orthologous to human SYDE2 (synapse defective Rho GTPase homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 2.9), lung adult (RPKM 2.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Syde2 in Genome Data Viewer
Location:
3; 3 H2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (145693160..145727475)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (145987405..146021720)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2410004B18 gene Neighboring gene VISTA enhancer mm311 Neighboring gene predicted gene, 35352 Neighboring gene predicted gene, 40166 Neighboring gene predicted gene, 35409 Neighboring gene dynein axonemal intermediate chain 3 Neighboring gene mucolipin 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in synaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
rho GTPase-activating protein SYDE2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166064.1NP_001159536.1  rho GTPase-activating protein SYDE2

    Status: VALIDATED

    Source sequence(s)
    AC123684, AK049496, CN702275
    Consensus CDS
    CCDS57259.1
    UniProtKB/TrEMBL
    E9PUP1, Q8BKW6
    Related
    ENSMUSP00000041897.7, ENSMUST00000039517.11
    Conserved Domains (2) summary
    cl02570
    Location:9351149
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl14603
    Location:800915
    C2; C2 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    145693160..145727475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501292.4XP_006501355.3  rho GTPase-activating protein SYDE2 isoform X1

    Conserved Domains (3) summary
    PHA03379
    Location:109326
    PHA03379; EBNA-3A; Provisional
    cl02570
    Location:9361150
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl14603
    Location:801916
    C2; C2 domain
  2. XM_006501293.2XP_006501356.1  rho GTPase-activating protein SYDE2 isoform X2

    Related
    ENSMUSP00000148542.2, ENSMUST00000212479.2
    Conserved Domains (2) summary
    cl02570
    Location:555769
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl14603
    Location:420535
    C2; C2 domain
  3. XM_006501294.2XP_006501357.1  rho GTPase-activating protein SYDE2 isoform X3

    Related
    ENSMUSP00000142954.2, ENSMUST00000200546.2
    Conserved Domains (2) summary
    cl02570
    Location:554768
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl14603
    Location:419534
    C2; C2 domain