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Sidt2 SID1 transmembrane family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 214597, updated on 5-Mar-2024

Summary

Official Symbol
Sidt2provided by MGI
Official Full Name
SID1 transmembrane family, member 2provided by MGI
Primary source
MGI:MGI:2446134
See related
Ensembl:ENSMUSG00000034908 AllianceGenome:MGI:2446134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGI-40; B930096O19
Summary
Enables several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and double-stranded RNA binding activity. Involved in RNA catabolic process and RNA transport. Acts upstream of or within several processes, including regulation of insulin secretion involved in cellular response to glucose stimulus; type B pancreatic cell development; and type B pancreatic cell proliferation. Located in lysosomal membrane and plasma membrane. Is expressed in several structures, including inner ear; submandibular gland primordium; and vibrissa. Used to study non-alcoholic fatty liver disease. Orthologous to human SIDT2 (SID1 transmembrane family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 124.6), ovary adult (RPKM 91.3) and 28 other tissues See more
Orthologs
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Genomic context

See Sidt2 in Genome Data Viewer
Location:
9 A5.2; 9 25.36 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45849155..45869299, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45937857..45958000, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 214 Neighboring gene STARR-seq mESC enhancer starr_24009 Neighboring gene predicted gene, 24646 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene RIKEN cDNA A830035O19 gene Neighboring gene transgelin Neighboring gene microRNA 7087 Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E8289 Neighboring gene STARR-seq mESC enhancer starr_24013 Neighboring gene STARR-seq mESC enhancer starr_24014 Neighboring gene predicted gene, 46110 Neighboring gene SIK family kinase 3 Neighboring gene STARR-seq mESC enhancer starr_24018

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC36407, MGC58967

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AP-1 adaptor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables AP-2 adaptor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
SID1 transmembrane family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289668.1NP_001276597.1  SID1 transmembrane family member 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001276597.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC122273
    Consensus CDS
    CCDS72225.1
    UniProtKB/Swiss-Prot
    Q8CIF6
    Related
    ENSMUSP00000110220.3, ENSMUST00000114573.9
    Conserved Domains (1) summary
    pfam13965
    Location:172853
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  2. NM_001359653.1NP_001346582.1  SID1 transmembrane family member 2 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon and has an alternate exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC122273
    Conserved Domains (1) summary
    pfam13965
    Location:170836
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  3. NM_172257.4NP_758461.1  SID1 transmembrane family member 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_758461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC122273, BQ179223, BQ749207, CA315096, CB247121, CF950439, CK639655
    Consensus CDS
    CCDS23138.1
    UniProtKB/Swiss-Prot
    Q80XD7, Q8CIF6, Q922R2
    UniProtKB/TrEMBL
    Q3U1L8
    Related
    ENSMUSP00000044290.10, ENSMUST00000038488.17
    Conserved Domains (1) summary
    pfam13965
    Location:172832
    SID-1_RNA_chan; dsRNA-gated channel SID-1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45849155..45869299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510144.4XP_006510207.1  SID1 transmembrane family member 2 isoform X4

    Conserved Domains (1) summary
    pfam13965
    Location:170857
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  2. XM_006510145.5XP_006510208.1  SID1 transmembrane family member 2 isoform X5

    Conserved Domains (1) summary
    pfam13965
    Location:170855
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  3. XM_006510143.5XP_006510206.1  SID1 transmembrane family member 2 isoform X3

    Conserved Domains (1) summary
    pfam13965
    Location:170876
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  4. XM_006510142.4XP_006510205.1  SID1 transmembrane family member 2 isoform X2

    Conserved Domains (1) summary
    pfam13965
    Location:170901
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  5. XM_006510141.3XP_006510204.1  SID1 transmembrane family member 2 isoform X1

    Conserved Domains (1) summary
    pfam13965
    Location:170922
    SID-1_RNA_chan; dsRNA-gated channel SID-1

RNA

  1. XR_003947838.2 RNA Sequence

  2. XR_004935375.1 RNA Sequence