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Aldh5a1 aldhehyde dehydrogenase family 5, subfamily A1 [ Mus musculus (house mouse) ]

Gene ID: 214579, updated on 7-Apr-2019

Summary

Official Symbol
Aldh5a1provided by MGI
Official Full Name
aldhehyde dehydrogenase family 5, subfamily A1provided by MGI
Primary source
MGI:MGI:2441982
See related
Ensembl:ENSMUSG00000035936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ahd1; Ahd-1; SSADH; Ssdh1; 6330403E24Rik; D630032B01Rik
Expression
Ubiquitous expression in cerebellum adult (RPKM 11.4), frontal lobe adult (RPKM 11.3) and 26 other tissues See more
Orthologs

Genomic context

See Aldh5a1 in Genome Data Viewer
Location:
13 A3.1; 13 10.77 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (24907579..24937661, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (24999448..25029530, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D130043K22 gene Neighboring gene tyrosyl-DNA phosphodiesterase 2 Neighboring gene RIKEN cDNA 4932702P03 gene Neighboring gene cDNA RIKEN 9330162012 gene Neighboring gene glycosylphosphatidylinositol specific phospholipase D1 Neighboring gene predicted gene, 34019 Neighboring gene MRS2 magnesium transporter

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAD binding ISO
Inferred from Sequence Orthology
more info
 
carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
succinate-semialdehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinate-semialdehyde dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
succinate-semialdehyde dehydrogenase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acetate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system development ISO
Inferred from Sequence Orthology
more info
 
galactosylceramide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
gamma-aminobutyric acid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
gamma-aminobutyric acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
gamma-aminobutyric acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucosylceramide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycerophospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
respiratory electron transport chain IMP
Inferred from Mutant Phenotype
more info
PubMed 
short-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
succinate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
succinate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
succinate-semialdehyde dehydrogenase, mitochondrial
Names
NAD(+)-dependent succinic semialdehyde dehydrogenase
aldehyde dehydrogenase 1, mitochondrial
aldehyde dehydrogenase family 5 member A1
aldehyde dehydrogenase family 5, subfamily A1
NP_766120.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172532.3NP_766120.1  succinate-semialdehyde dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_766120.1

    Status: VALIDATED

    Source sequence(s)
    AK052703, AK144030, AK164287, CB723582
    Consensus CDS
    CCDS26383.1
    UniProtKB/Swiss-Prot
    Q8BWF0
    UniProtKB/TrEMBL
    B2RS41
    Related
    ENSMUSP00000040591.6, ENSMUST00000037615.6
    Conserved Domains (1) summary
    TIGR01780
    Location:66516
    SSADH; succinate-semialdehyde dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    24907579..24937661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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