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She src homology 2 domain-containing transforming protein E [ Mus musculus (house mouse) ]

Gene ID: 214547, updated on 1-Mar-2024

Summary

Official Symbol
Sheprovided by MGI
Official Full Name
src homology 2 domain-containing transforming protein Eprovided by MGI
Primary source
MGI:MGI:1099462
See related
Ensembl:ENSMUSG00000046280 AllianceGenome:MGI:1099462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9430022A14
Summary
Predicted to enable phosphotyrosine residue binding activity. Is expressed in embryo mesenchyme. Orthologous to human SHE (Src homology 2 domain containing E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 7.4), ovary adult (RPKM 2.5) and 21 other tissues See more
Orthologs
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Genomic context

See She in Genome Data Viewer
Location:
3 F1; 3 39.19 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89738667..89766149)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89831370..89858846)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2Q family member 1 Neighboring gene STARR-seq mESC enhancer starr_08252 Neighboring gene STARR-seq mESC enhancer starr_08253 Neighboring gene STARR-positive B cell enhancer ABC_E2083 Neighboring gene STARR-seq mESC enhancer starr_08257 Neighboring gene predicted gene 8969 Neighboring gene STARR-positive B cell enhancer ABC_E9217 Neighboring gene STARR-positive B cell enhancer ABC_E4556 Neighboring gene interleukin 6 receptor, alpha Neighboring gene STARR-seq mESC enhancer starr_08265 Neighboring gene STARR-positive B cell enhancer ABC_E2670 Neighboring gene STARR-seq mESC enhancer starr_08266 Neighboring gene STARR-positive B cell enhancer ABC_E7921 Neighboring gene ATPase, class I, type 8B, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E7922

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Clone Names

  • MGC130415

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
SH2 domain-containing adapter protein E
Names
Src homology 2 domain containing E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411269.1NP_001398198.1  SH2 domain-containing adapter protein E isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102392
  2. NM_172530.4NP_766118.3  SH2 domain-containing adapter protein E isoform 1

    See identical proteins and their annotated locations for NP_766118.3

    Status: VALIDATED

    Source sequence(s)
    AC102392
    Consensus CDS
    CCDS17518.1
    UniProtKB/Swiss-Prot
    Q3TZT0, Q8BSD5
    Related
    ENSMUSP00000059658.6, ENSMUST00000050401.6
    Conserved Domains (1) summary
    cd10391
    Location:391488
    SH2_SHE; Src homology 2 domain found in SH2 domain-containing adapter protein E (SHE)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89738667..89766149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)