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Cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component [ Mus musculus (house mouse) ]

Gene ID: 214498, updated on 8-Dec-2022

Summary

Official Symbol
Cdc73provided by MGI
Official Full Name
cell division cycle 73, Paf1/RNA polymerase II complex componentprovided by MGI
Primary source
MGI:MGI:2384876
See related
Ensembl:ENSMUSG00000026361 AllianceGenome:MGI:2384876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hrpt2; 8430414L16Rik; C130030P16Rik
Summary
Predicted to enable RNA polymerase II complex binding activity. Involved in several processes, including cellular response to lipopolysaccharide; endodermal cell fate commitment; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of apoptotic process; regulation of cell growth; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Used to study hyperparathyroidism. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 8.5), CNS E11.5 (RPKM 3.0) and 19 other tissues See more
Orthologs
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Genomic context

See Cdc73 in Genome Data Viewer
Location:
1 F; 1 62.52 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (143479014..143578631, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (143603276..143702893, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35244 Neighboring gene predicted gene, 35303 Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 38658 Neighboring gene predicted gene, 46161 Neighboring gene glutaredoxin 2 (thioltransferase)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29274, MGC36559

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endodermal cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H2B ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in histone modification IEA
Inferred from Electronic Annotation
more info
 
involved_in histone monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA polyadenylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cdc73/Paf1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cdc73/Paf1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
parafibromin
Names
cell division cycle protein 73 homolog
hyperparathyroidism 2 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145991.2NP_666103.1  parafibromin

    See identical proteins and their annotated locations for NP_666103.1

    Status: VALIDATED

    Source sequence(s)
    AK048027, AK080861, AK134896, AK153645, AL592403, BB645172
    Consensus CDS
    CCDS15341.1
    UniProtKB/Swiss-Prot
    Q8JZM7
    UniProtKB/TrEMBL
    A0A6P5PR85, A0A8C6MS23, Q3U5E6
    Related
    ENSMUSP00000018337.8, ENSMUST00000018337.9
    Conserved Domains (2) summary
    pfam05179
    Location:357520
    CDC73_C; RNA pol II accessory factor, Cdc73 family, C-terminal
    pfam16050
    Location:1297
    CDC73_N; Paf1 complex subunit CDC73 N-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    143479014..143578631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529366.4XP_006529429.1  parafibromin isoform X2

    Conserved Domains (1) summary
    pfam16050
    Location:1297
    CDC73_N; Paf1 complex subunit CDC73 N-terminal
  2. XM_006529365.2XP_006529428.1  parafibromin isoform X1

    Conserved Domains (1) summary
    pfam16050
    Location:1297
    CDC73_N; Paf1 complex subunit CDC73 N-terminal