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Myocd myocardin [ Mus musculus (house mouse) ]

Gene ID: 214384, updated on 18-Sep-2024

Summary

Official Symbol
Myocdprovided by MGI
Official Full Name
myocardinprovided by MGI
Primary source
MGI:MGI:2137495
See related
Ensembl:ENSMUSG00000020542 AllianceGenome:MGI:2137495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Srfcp; BSAC2A
Summary
Enables several functions, including R-SMAD binding activity; enzyme binding activity; and transcription coactivator activity. Involved in several processes, including circulatory system development; negative regulation of vascular associated smooth muscle cell migration; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; circulatory system development; and regulation of transcription, DNA-templated. Located in chromatin and nucleus. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; paraxial mesenchyme; and respiratory system. Used to study bladder disease; dilated cardiomyopathy; and patent ductus arteriosus. Human ortholog(s) of this gene implicated in congenital megabladder. Orthologous to human MYOCD (myocardin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 12.8), heart adult (RPKM 7.0) and 6 other tissues See more
Orthologs
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Genomic context

See Myocd in Genome Data Viewer
Location:
11 B3; 11 40.42 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (65064434..65160821, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (65173608..65269989, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 44 Neighboring gene RIKEN cDNA 1700086D15 gene Neighboring gene STARR-seq mESC enhancer starr_29766 Neighboring gene predicted gene, 53042 Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene VISTA enhancer mm67 Neighboring gene predicted gene, 30586 Neighboring gene predicted gene 12295 Neighboring gene STARR-seq mESC enhancer starr_29767 Neighboring gene STARR-seq mESC enhancer starr_29768 Neighboring gene STARR-seq mESC enhancer starr_29770 Neighboring gene predicted gene, 53667

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables R-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle cell myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac vascular smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac ventricle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular component maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ductus arteriosus closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hepatic stellate cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of cell adhesion molecule production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of platelet-derived growth factor receptor-beta signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of miRNA transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell growth by extracellular stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of phenotypic switching IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in smooth muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transcription initiation-coupled chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within urinary bladder development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in urinary bladder development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within uterus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular associated smooth muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of SRF-myogenin-E12 complex IC
Inferred by Curator
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myocardin
Names
SRF co-factor protein (cardiac and smooth muscle)
SRF cofactor protein
basic SAP coiled-coil transcription activator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145136.5NP_660118.3  myocardin isoform A

    See identical proteins and their annotated locations for NP_660118.3

    Status: VALIDATED

    Source sequence(s)
    AL669846
    Consensus CDS
    CCDS48819.1
    UniProtKB/TrEMBL
    B9EJ16
    Related
    ENSMUSP00000104335.3, ENSMUST00000108695.9
    Conserved Domains (2) summary
    smart00707
    Location:106131
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:380413
    SAP; SAP domain
  2. NM_146386.4NP_666498.2  myocardin isoform B

    See identical proteins and their annotated locations for NP_666498.2

    Status: VALIDATED

    Source sequence(s)
    AL669846
    Consensus CDS
    CCDS24843.1
    UniProtKB/Swiss-Prot
    Q5SS65, Q6W8X1, Q8C3W6, Q8VIL4, Q8VIM5
    UniProtKB/TrEMBL
    B9EJ16
    Related
    ENSMUSP00000099695.4, ENSMUST00000102635.10
    Conserved Domains (2) summary
    smart00707
    Location:106131
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:380413
    SAP; SAP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    65064434..65160821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248893.3XP_011247195.1  myocardin isoform X1

    UniProtKB/TrEMBL
    B9EJ16
    Conserved Domains (2) summary
    smart00707
    Location:119144
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:396426
    SAP; SAP domain
  2. XM_011248895.1XP_011247197.1  myocardin isoform X2

    UniProtKB/TrEMBL
    B9EJ16
    Related
    ENSMUSP00000098603.3, ENSMUST00000101042.9
    Conserved Domains (2) summary
    smart00707
    Location:2752
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:304334
    SAP; SAP domain