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Tut7 terminal uridylyl transferase 7 [ Mus musculus (house mouse) ]

Gene ID: 214290, updated on 4-Jan-2025

Summary

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Official Symbol
Tut7provided by MGI
Official Full Name
terminal uridylyl transferase 7provided by MGI
Primary source
MGI:MGI:2387179
See related
Ensembl:ENSMUSG00000035248 AllianceGenome:MGI:2387179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tent3b; Zcchc6; 6030448M23Rik
Summary
Enables uridylyltransferase activity. Involved in RNA 3' uridylation; oocyte maturation; and polyuridylation-dependent mRNA catabolic process. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including autopod; early conceptus; genitourinary system; sensory organ; and skeleton. Orthologous to human TUT7 (terminal uridylyl transferase 7). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in liver E14 (RPKM 11.4), liver E14.5 (RPKM 9.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tut7 in Genome Data Viewer
Location:
13 B2; 13 31.88 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (59919690..59971060, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (59771876..59823169, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 31 subfamily D, member 1E Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:59871197-59871469 Neighboring gene iron-sulfur cluster assembly 1 Neighboring gene ethanol decreased 2 Neighboring gene STARR-seq mESC enhancer starr_34725 Neighboring gene predicted gene, 19866 Neighboring gene STARR-seq mESC enhancer starr_34726 Neighboring gene STARR-seq mESC enhancer starr_34727 Neighboring gene predicted gene, 35143

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation. Lin CC, et al. Nat Commun, 2021 Jun 29. PMID 34188032, Free PMC Article
  2. TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication. Gupta A, et al. Commun Biol, 2023 Apr 21. PMID 37085578, Free PMC Article
  3. Genetic Inactivation of ZCCHC6 Suppresses Interleukin-6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice. Ansari MY, et al. Arthritis Rheumatol, 2019 Apr. PMID 30302948, Free PMC Article
  4. The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses. Kozlowski E, et al. PLoS One, 2017. PMID 28665939, Free PMC Article
  5. A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis. Morgan M, et al. Cell Res, 2019 Mar. PMID 30617251, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication.
    Title: TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication.
  2. Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation.
    Title: Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation.
  3. ZCCHC6 (TUT7) was markedly up-regulated in damaged cartilage from human osteoarthritis (OA) patients and from wild-type mice with surgically induced OA.
    Title: Genetic Inactivation of ZCCHC6 Suppresses Interleukin-6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice.
  4. Following an intratracheal challenge with S. pneumoniae, Zcchc6 deficiency led to a modest but significant increase in the expression of select cytokines including IL-6, CXCL1, and CXCL5. These findings were recapitulated in vitro whereby Zcchc6-deficient macrophages exhibited similar increases in cytokine expression due to bacterial stimulation
    Title: The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38585

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA uridylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA uridylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA uridylyltransferase activity TAS
Traceable Author Statement
more info
  
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables uridylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables uridylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables uridylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA 3' uridylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA 3' uridylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA 3' uridylation ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA 3' uridylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in RNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA 3'-end processing ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in histone mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in miRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyuridylation-dependent mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pre-miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in pre-miRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transposable element silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in transposable element silencing by mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
terminal uridylyltransferase 7
Names
TUTase 7
zinc finger CCHC domain-containing protein 6
zinc finger, CCHC domain containing 6
NP_001360891.1
NP_001360892.1
NP_001360893.1
NP_705766.3
XP_006517270.1
XP_006517272.1
XP_036013864.1
XP_036013865.1
XP_036013866.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373962.1 → NP_001360891.1  terminal uridylyltransferase 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125350, AC134869
    UniProtKB/Swiss-Prot
    A1A4B1, Q3V3V7, Q5BLK4, Q8CIH3
    Conserved Domains (6) summary
    smart00343
    Location:1448 → 1464
    ZnF_C2HC; zinc finger
    COG5260
    Location:975 → 1306
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    TIGR00927
    Location:673 → 910
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam03828
    Location:550 → 599
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1365 → 1446
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    pfam19088
    Location:205 → 539
    TUTase; TUTase nucleotidyltransferase domain

  2. NM_001373963.1 → NP_001360892.1  terminal uridylyltransferase 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125350, AC134869
    UniProtKB/Swiss-Prot
    A1A4B1, Q3V3V7, Q5BLK4, Q8CIH3
    Conserved Domains (6) summary
    smart00343
    Location:1448 → 1464
    ZnF_C2HC; zinc finger
    COG5260
    Location:975 → 1306
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    TIGR00927
    Location:673 → 910
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam03828
    Location:550 → 599
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1365 → 1446
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    pfam19088
    Location:205 → 539
    TUTase; TUTase nucleotidyltransferase domain

  3. NM_001373964.1 → NP_001360893.1  terminal uridylyltransferase 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125350, AC134869
    Conserved Domains (6) summary
    smart00343
    Location:1448 → 1464
    ZnF_C2HC; zinc finger
    COG5260
    Location:975 → 1306
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    TIGR00927
    Location:673 → 910
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam03828
    Location:550 → 599
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1365 → 1446
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    pfam19088
    Location:205 → 539
    TUTase; TUTase nucleotidyltransferase domain

  4. NM_153538.3 → NP_705766.3  terminal uridylyltransferase 7 isoform 2

    See identical proteins and their annotated locations for NP_705766.3

    Status: VALIDATED

    Source sequence(s)
    BC043111, CB526652, CJ054882
    Consensus CDS
    CCDS36689.1
    UniProtKB/TrEMBL
    E9PUA2
    Related
    ENSMUSP00000071623.5, ENSMUST00000071703.6
    Conserved Domains (6) summary
    smart00343
    Location:1448 → 1464
    ZnF_C2HC; zinc finger
    COG5260
    Location:975 → 1306
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    TIGR00927
    Location:673 → 910
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam03828
    Location:550 → 599
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1365 → 1446
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    pfam19088
    Location:205 → 539
    TUTase; TUTase nucleotidyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    59919690..59971060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157972.1 → XP_036013865.1  terminal uridylyltransferase 7 isoform X2

    UniProtKB/Swiss-Prot
    A1A4B1, Q3V3V7, Q5BLK4, Q8CIH3
    Conserved Domains (6) summary
    smart00343
    Location:1448 → 1464
    ZnF_C2HC; zinc finger
    COG5260
    Location:975 → 1306
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    TIGR00927
    Location:673 → 910
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam03828
    Location:550 → 599
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1365 → 1446
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    pfam19088
    Location:205 → 539
    TUTase; TUTase nucleotidyltransferase domain

  2. XM_036157971.1 → XP_036013864.1  terminal uridylyltransferase 7 isoform X1

    Conserved Domains (6) summary
    smart00343
    Location:1448 → 1464
    ZnF_C2HC; zinc finger
    COG5260
    Location:975 → 1306
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    TIGR00927
    Location:673 → 910
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam03828
    Location:550 → 599
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1365 → 1446
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    pfam19088
    Location:205 → 539
    TUTase; TUTase nucleotidyltransferase domain

  3. XM_006517209.3 → XP_006517272.1  terminal uridylyltransferase 7 isoform X3

    See identical proteins and their annotated locations for XP_006517272.1

    UniProtKB/TrEMBL
    E9PUA2
    Conserved Domains (6) summary
    smart00343
    Location:1448 → 1464
    ZnF_C2HC; zinc finger
    COG5260
    Location:975 → 1306
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    TIGR00927
    Location:673 → 910
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam03828
    Location:550 → 599
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1365 → 1446
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    pfam19088
    Location:205 → 539
    TUTase; TUTase nucleotidyltransferase domain

  4. XM_006517207.3 → XP_006517270.1  terminal uridylyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_006517270.1

    Conserved Domains (6) summary
    smart00343
    Location:1448 → 1464
    ZnF_C2HC; zinc finger
    COG5260
    Location:975 → 1306
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    TIGR00927
    Location:673 → 910
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam03828
    Location:550 → 599
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1365 → 1446
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    pfam19088
    Location:205 → 539
    TUTase; TUTase nucleotidyltransferase domain

  5. XM_036157973.1 → XP_036013866.1  terminal uridylyltransferase 7 isoform X3

    UniProtKB/TrEMBL
    E9PUA2
    Conserved Domains (6) summary
    smart00343
    Location:1448 → 1464
    ZnF_C2HC; zinc finger
    COG5260
    Location:975 → 1306
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    TIGR00927
    Location:673 → 910
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam03828
    Location:550 → 599
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1365 → 1446
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    pfam19088
    Location:205 → 539
    TUTase; TUTase nucleotidyltransferase domain

RNA

  1. XR_003950443.2 RNA Sequence

  2. XR_004938011.1 RNA Sequence

  3. XR_004938012.1 RNA Sequence

  4. XR_003950441.2 RNA Sequence

  5. XR_003950442.1 RNA Sequence

  6. XR_004938010.1 RNA Sequence

    Related
    ENSMUST00000224480.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BLK4.3 GenPept UniProtKB/Swiss-Prot:Q5BLK4

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