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Tfec transcription factor EC [ Mus musculus (house mouse) ]

Gene ID: 21426, updated on 17-Dec-2020

Summary

Official Symbol
Tfecprovided by MGI
Official Full Name
transcription factor ECprovided by MGI
Primary source
MGI:MGI:1333760
See related
Ensembl:ENSMUSG00000029553
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcfec; bHLHe3; bHLHe34; BB107417
Expression
Biased expression in placenta adult (RPKM 1.9), liver E18 (RPKM 1.4) and 12 other tissues See more
Orthologs
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Genomic context

See Tfec in Genome Data Viewer
Location:
6; 6 A2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (16830926..16898463, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (16830927..16898464, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (16783381..16848441, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36503 Neighboring gene predicted gene, 36669 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase pseudogene Neighboring gene predicted gene 15473 Neighboring gene testin LIM domain protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107474

Gene Ontology Provided by MGI

Process Evidence Code Pubs
cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor EC
Names
TFE-C
mTFEC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031198.3NP_112475.1  transcription factor EC

    See identical proteins and their annotated locations for NP_112475.1

    Status: VALIDATED

    Source sequence(s)
    AC102663, AK137141
    Consensus CDS
    CCDS19920.1
    UniProtKB/Swiss-Prot
    Q9WTW4
    Related
    ENSMUSP00000031533.7, ENSMUST00000031533.10
    Conserved Domains (3) summary
    cd00083
    Location:108168
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:196300
    DUF3371; Domain of unknown function (DUF3371)
    cl21462
    Location:164195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    16830926..16898463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241053.3XP_011239355.1  transcription factor EC isoform X2

    Conserved Domains (2) summary
    pfam11851
    Location:213317
    DUF3371; Domain of unknown function (DUF3371)
    cl00081
    Location:148219
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  2. XM_006505035.5XP_006505098.1  transcription factor EC isoform X1

    Conserved Domains (2) summary
    pfam11851
    Location:232336
    DUF3371; Domain of unknown function (DUF3371)
    cd18926
    Location:135238
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
  3. XM_017321504.2XP_017176993.1  transcription factor EC isoform X4

    Conserved Domains (2) summary
    pfam11851
    Location:97201
    DUF3371; Domain of unknown function (DUF3371)
    cl00081
    Location:32103
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  4. XM_006505036.4XP_006505099.1  transcription factor EC isoform X3

    Conserved Domains (2) summary
    pfam11851
    Location:158262
    DUF3371; Domain of unknown function (DUF3371)
    cd18926
    Location:61164
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
  5. XM_006505037.4XP_006505100.1  transcription factor EC isoform X4

    Conserved Domains (2) summary
    pfam11851
    Location:97201
    DUF3371; Domain of unknown function (DUF3371)
    cl00081
    Location:32103
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
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