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Tfec transcription factor EC [ Mus musculus (house mouse) ]

Gene ID: 21426, updated on 31-Jan-2019

Summary

Official Symbol
Tfecprovided by MGI
Official Full Name
transcription factor ECprovided by MGI
Primary source
MGI:MGI:1333760
See related
Ensembl:ENSMUSG00000029553
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcfec; bHLHe34; BB107417
Expression
Biased expression in placenta adult (RPKM 1.9), liver E18 (RPKM 1.4) and 12 other tissues See more
Orthologs

Genomic context

See Tfec in Genome Data Viewer
Location:
6; 6 A2
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (16830927..16898466, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (16783381..16848441, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36503 Neighboring gene predicted gene, 36669 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase pseudogene Neighboring gene predicted gene 15473

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • MGC107474

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcription factor EC
Names
TFE-C
mTFEC

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031198.3NP_112475.1  transcription factor EC

    See identical proteins and their annotated locations for NP_112475.1

    Status: VALIDATED

    Source sequence(s)
    AC102663, AK137141
    Consensus CDS
    CCDS19920.1
    UniProtKB/Swiss-Prot
    Q9WTW4
    Related
    ENSMUSP00000031533.7, ENSMUST00000031533.10
    Conserved Domains (3) summary
    cd00083
    Location:108168
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:196300
    DUF3371; Domain of unknown function (DUF3371)
    cl21462
    Location:164195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    16830927..16898466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241053.2XP_011239355.1  transcription factor EC isoform X2

    Conserved Domains (3) summary
    cd00083
    Location:148185
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam07716
    Location:181212
    bZIP_2; Basic region leucine zipper
    pfam11851
    Location:213317
    DUF3371; Domain of unknown function (DUF3371)
  2. XM_006505035.3XP_006505098.1  transcription factor EC isoform X1

    Conserved Domains (3) summary
    cd00083
    Location:144204
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:232336
    DUF3371; Domain of unknown function (DUF3371)
    cl21462
    Location:200231
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  3. XM_017321504.1XP_017176993.1  transcription factor EC isoform X4

    Conserved Domains (3) summary
    smart00353
    Location:2469
    HLH; helix loop helix domain
    pfam11851
    Location:97201
    DUF3371; Domain of unknown function (DUF3371)
    cl21462
    Location:6596
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  4. XM_006505036.3XP_006505099.1  transcription factor EC isoform X3

    Conserved Domains (2) summary
    cd00083
    Location:70130
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:158262
    DUF3371; Domain of unknown function (DUF3371)
  5. XM_006505037.3XP_006505100.1  transcription factor EC isoform X4

    Conserved Domains (3) summary
    smart00353
    Location:2469
    HLH; helix loop helix domain
    pfam11851
    Location:97201
    DUF3371; Domain of unknown function (DUF3371)
    cl21462
    Location:6596
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
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