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Skp1 S-phase kinase-associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 21402, updated on 5-Mar-2024

Summary

Official Symbol
Skp1provided by MGI
Official Full Name
S-phase kinase-associated protein 1provided by MGI
Primary source
MGI:MGI:103575
See related
Ensembl:ENSMUSG00000036309 AllianceGenome:MGI:103575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OCP2; p19A; 15kDa; EMC19; Skp1a; OCP-II; Tceb1l; p19Skp1; 2610043E24Rik; 2610206H23Rik
Summary
Predicted to enable several functions, including F-box domain binding activity; beta-catenin binding activity; and cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within protein K48-linked ubiquitination and protein monoubiquitination. Located in centrosome and cytosol. Part of Cul7-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; notochord; and sensory organ. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 68.9), CNS E11.5 (RPKM 64.4) and 22 other tissues See more
Orthologs
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Genomic context

See Skp1 in Genome Data Viewer
Location:
11 B1.3; 11 31.86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (52121349..52137685)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52230522..52246858)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12206 Neighboring gene STARR-seq mESC enhancer starr_29443 Neighboring gene STARR-seq mESC enhancer starr_29444 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52045093-52045276 Neighboring gene STARR-positive B cell enhancer ABC_E8401 Neighboring gene olfactory receptor family 2 subfamily Y member 6 Neighboring gene transcription factor 7, T cell specific Neighboring gene STARR-seq mESC enhancer starr_29449 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52096181-52096290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52097872-52098055 Neighboring gene STARR-seq mESC enhancer starr_29452 Neighboring gene STARR-seq mESC enhancer starr_29453 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52132162-52132271 Neighboring gene predicted gene, 30217 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52152988-52153277 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52154886-52154995 Neighboring gene STARR-positive B cell enhancer ABC_E11479 Neighboring gene STARR-seq mESC enhancer starr_29458 Neighboring gene voltage-dependent anion channel 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables F-box domain binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin ligase complex scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin-protein transferase activity IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
part_of Cul7-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Cul7-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in gap junction ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
S-phase kinase-associated protein 1
Names
S-phase kinase-associated protein 1A
cyclin-A/CDK2-associated protein p19
NP_035673.3
XP_006532849.1
XP_036012398.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011543.4NP_035673.3  S-phase kinase-associated protein 1

    See identical proteins and their annotated locations for NP_035673.3

    Status: VALIDATED

    Source sequence(s)
    AK012498, AK078330, BU841654
    Consensus CDS
    CCDS24669.1
    UniProtKB/Swiss-Prot
    Q8C5H6, Q9WTX5
    UniProtKB/TrEMBL
    Q3TL58, Q5SUR3
    Related
    ENSMUSP00000038744.6, ENSMUST00000037324.12
    Conserved Domains (2) summary
    cd18322
    Location:3127
    BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
    pfam01466
    Location:113160
    Skp1; Skp1 family, dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    52121349..52137685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532786.2XP_006532849.1  S-phase kinase-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006532849.1

    UniProtKB/Swiss-Prot
    Q8C5H6, Q9WTX5
    UniProtKB/TrEMBL
    Q3TL58, Q5SUR3
    Conserved Domains (2) summary
    cd18322
    Location:3127
    BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
    pfam01466
    Location:113160
    Skp1; Skp1 family, dimerization domain
  2. XM_036156505.1XP_036012398.1  S-phase kinase-associated protein 1 isoform X2

    Conserved Domains (2) summary
    cd18322
    Location:292
    BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
    pfam01466
    Location:78125
    Skp1; Skp1 family, dimerization domain