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Ccdc186 coiled-coil domain containing 186 [ Mus musculus (house mouse) ]

Gene ID: 213993, updated on 21-Apr-2024

Summary

Official Symbol
Ccdc186provided by MGI
Official Full Name
coiled-coil domain containing 186provided by MGI
Primary source
MGI:MGI:2445022
See related
Ensembl:ENSMUSG00000035173 AllianceGenome:MGI:2445022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Otg1; 1810028B20Rik; A630007B06Rik
Summary
Predicted to enable small GTPase binding activity. Acts upstream of or within insulin secretion involved in cellular response to glucose stimulus; response to bacterium; and vesicle cytoskeletal trafficking. Located in Golgi apparatus. Is expressed in brain. Orthologous to human CCDC186 (coiled-coil domain containing 186). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.0), CNS E14 (RPKM 4.5) and 28 other tissues See more
Orthologs
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Genomic context

Location:
19 D2; 19 51.99 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (56775917..56810631, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (56787485..56822199, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene adrenergic receptor, beta 1 Neighboring gene predicted gene, 32718 Neighboring gene rp1 MIF pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5712 Neighboring gene tudor domain containing 1 Neighboring gene von Willebrand factor A domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1)  1 citation
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

General protein information

Preferred Names
coiled-coil domain-containing protein 186
Names
oocyte-testis gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_170757.2NP_739563.1  coiled-coil domain-containing protein 186

    See identical proteins and their annotated locations for NP_739563.1

    Status: VALIDATED

    Source sequence(s)
    AC158549
    Consensus CDS
    CCDS29921.1
    UniProtKB/Swiss-Prot
    Q6P3D6, Q8C9S4, Q8CJC0
    Related
    ENSMUSP00000113457.2, ENSMUST00000118592.8
    Conserved Domains (1) summary
    pfam09728
    Location:315645
    Taxilin; Myosin-like coiled-coil protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    56775917..56810631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526852.2XP_006526915.1  coiled-coil domain-containing protein 186 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:159533
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:42324
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type