U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [ Mus musculus (house mouse) ]

Gene ID: 213990, updated on 8-Jan-2023

Summary

Official Symbol
Agap3provided by MGI
Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3provided by MGI
Primary source
MGI:MGI:2183446
See related
Ensembl:ENSMUSG00000023353 AllianceGenome:MGI:2183446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crag; Crag.; AGAP-3; Centg3; MRIP-1; cnt-g3
Summary
Enables GTPase activity and polyubiquitin modification-dependent protein binding activity. Acts upstream of or within cellular response to reactive oxygen species; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein import into nucleus. Located in cell periphery; cytoplasm; and nucleus. Orthologous to human AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 21.6), cortex adult (RPKM 20.9) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Agap3 in Genome Data Viewer
Location:
5; 5 A3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24657175..24707045)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24452177..24502047)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Fas-activated serine/threonine kinase Neighboring gene transmembrane and ubiquitin-like domain containing 1 Neighboring gene VISTA enhancer mm1191 Neighboring gene gastrulation brain homeobox 1 Neighboring gene ankyrin repeat and SOCS box-containing 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC37541

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
Names
CRAM-associated GTPase
MR1-interacting protein
centaurin, gamma 3
spidin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256431.1NP_001243360.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC120353
    Related
    ENSMUSP00000148770.2, ENSMUST00000212381.2
    Conserved Domains (2) summary
    cd04103
    Location:127284
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00010
    Location:125290
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
  2. NM_001359881.1NP_001346810.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC120353
    Conserved Domains (5) summary
    cd04103
    Location:127284
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd00204
    Location:685774
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:400541
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:685715
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:560674
    ArfGap; Putative GTPase activating protein for Arf
  3. NM_139153.2NP_631892.2  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform a

    See identical proteins and their annotated locations for NP_631892.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC120353, AK079516, AV241066, BM943676, BM943884, CJ052480, CJ053222
    Consensus CDS
    CCDS19122.1
    UniProtKB/TrEMBL
    F8VQE9, Q8BV81
    Related
    ENSMUSP00000024123.5, ENSMUST00000024123.9
    Conserved Domains (6) summary
    cd04103
    Location:127284
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    PRK07003
    Location:462573
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01250
    Location:400644
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:788818
    ANK; ANK repeat [structural motif]
    cd08855
    Location:660769
    ArfGap_AGAP3; ArfGAP with GTPase domain, ANK repeat and PH domain 3
    pfam12796
    Location:788878
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    24657175..24707045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535676.5XP_006535739.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JDW1
    Related
    ENSMUSP00000142529.2, ENSMUST00000199856.2
    Conserved Domains (1) summary
    cd04103
    Location:310467
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
  2. XM_006535673.5XP_006535736.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1

    Conserved Domains (6) summary
    cd04103
    Location:310467
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    PRK07003
    Location:645756
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01250
    Location:583827
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:9711001
    ANK; ANK repeat [structural motif]
    cd08855
    Location:843952
    ArfGap_AGAP3; ArfGAP with GTPase domain, ANK repeat and PH domain 3
    pfam12796
    Location:9711061
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_006535674.5XP_006535737.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X2

    Conserved Domains (5) summary
    cd04103
    Location:310467
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd01250
    Location:583781
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:925955
    ANK; ANK repeat [structural motif]
    cd08855
    Location:797906
    ArfGap_AGAP3; ArfGAP with GTPase domain, ANK repeat and PH domain 3
    pfam12796
    Location:9251015
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_006535675.5XP_006535738.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X3

    Conserved Domains (5) summary
    cd04103
    Location:310467
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd01250
    Location:583724
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:868898
    ANK; ANK repeat [structural motif]
    cd08855
    Location:740849
    ArfGap_AGAP3; ArfGAP with GTPase domain, ANK repeat and PH domain 3
    pfam12796
    Location:868958
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_006535677.4XP_006535740.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X5

    Conserved Domains (5) summary
    PRK07003
    Location:117228
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01250
    Location:55299
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:443473
    ANK; ANK repeat [structural motif]
    cd08855
    Location:315424
    ArfGap_AGAP3; ArfGAP with GTPase domain, ANK repeat and PH domain 3
    pfam12796
    Location:443533
    Ank_2; Ankyrin repeats (3 copies)
  6. XM_030254355.1XP_030110215.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X6

    Related
    ENSMUSP00000142875.2, ENSMUST00000197513.2
    Conserved Domains (4) summary
    cd01250
    Location:55196
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:340370
    ANK; ANK repeat [structural motif]
    cd08855
    Location:212321
    ArfGap_AGAP3; ArfGAP with GTPase domain, ANK repeat and PH domain 3
    pfam12796
    Location:340430
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_001784662.3 RNA Sequence

  2. XR_001784661.3 RNA Sequence