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Tbxas1 thromboxane A synthase 1, platelet [ Mus musculus (house mouse) ]

Gene ID: 21391, updated on 12-Jun-2019

Summary

Official Symbol
Tbxas1provided by MGI
Official Full Name
thromboxane A synthase 1, plateletprovided by MGI
Primary source
MGI:MGI:98497
See related
Ensembl:ENSMUSG00000029925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TS; TXS; CYP5; THAS; TXAS; CYP5A1
Expression
Broad expression in kidney adult (RPKM 4.2), spleen adult (RPKM 3.2) and 22 other tissues See more
Orthologs

Genomic context

See Tbxas1 in Genome Data Viewer
Location:
6 B1; 6 17.85 cM
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (38875377..39084590)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (38868985..39034578)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38496 Neighboring gene homeodomain interacting protein kinase 2 Neighboring gene RIKEN cDNA 4930502C15 gene Neighboring gene predicted gene, 46988 Neighboring gene predicted gene, 33767 Neighboring gene predicted gene, 38688 Neighboring gene predicted gene, 38489 Neighboring gene RIKEN cDNA 1700025N23 gene Neighboring gene predicted gene, 46989 Neighboring gene RIKEN cDNA 4930599N23 gene Neighboring gene poly (ADP-ribose) polymerase family, member 12 Neighboring gene lysine (K)-specific demethylase 7A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
thromboxane-A synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thromboxane-A synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cellular chloride ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thromboxane-A synthase
Names
TXA synthase
cytochrome P450 5A1
thromboxane synthase
NP_035669.3
XP_006505939.1
XP_006505940.1
XP_006505941.1
XP_006505942.1
XP_006505943.1
XP_006505944.1
XP_011239582.1
XP_017176988.1
XP_017176989.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011539.3NP_035669.3  thromboxane-A synthase

    See identical proteins and their annotated locations for NP_035669.3

    Status: VALIDATED

    Source sequence(s)
    AC125327, AK139479, AW046906
    Consensus CDS
    CCDS20018.1
    UniProtKB/Swiss-Prot
    P36423
    UniProtKB/TrEMBL
    Q3UTF0
    Related
    ENSMUSP00000003017.6, ENSMUST00000003017.12
    Conserved Domains (1) summary
    pfam00067
    Location:47530
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    38875377..39084590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321499.1XP_017176988.1  thromboxane-A synthase isoform X1

    UniProtKB/Swiss-Prot
    P36423
    Conserved Domains (1) summary
    pfam00067
    Location:47530
    p450; Cytochrome P450
  2. XM_017321500.1XP_017176989.1  thromboxane-A synthase isoform X1

    UniProtKB/Swiss-Prot
    P36423
    Conserved Domains (1) summary
    pfam00067
    Location:47530
    p450; Cytochrome P450
  3. XM_011241280.2XP_011239582.1  thromboxane-A synthase isoform X1

    See identical proteins and their annotated locations for XP_011239582.1

    UniProtKB/Swiss-Prot
    P36423
    Conserved Domains (1) summary
    pfam00067
    Location:47530
    p450; Cytochrome P450
  4. XM_006505881.2XP_006505944.1  thromboxane-A synthase isoform X7

    Conserved Domains (1) summary
    cl12078
    Location:47378
    p450; Cytochrome P450
  5. XM_006505878.2XP_006505941.1  thromboxane-A synthase isoform X4

    Conserved Domains (1) summary
    cl12078
    Location:47456
    p450; Cytochrome P450
  6. XM_006505877.3XP_006505940.1  thromboxane-A synthase isoform X3

    Conserved Domains (1) summary
    pfam00067
    Location:47491
    p450; Cytochrome P450
  7. XM_006505879.3XP_006505942.1  thromboxane-A synthase isoform X5

    Conserved Domains (1) summary
    cl12078
    Location:47455
    p450; Cytochrome P450
  8. XM_006505876.3XP_006505939.1  thromboxane-A synthase isoform X2

    Conserved Domains (1) summary
    pfam00067
    Location:47530
    p450; Cytochrome P450
  9. XM_006505880.3XP_006505943.1  thromboxane-A synthase isoform X6

    Conserved Domains (1) summary
    pfam00067
    Location:6412
    p450; Cytochrome P450
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