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Cntn2 contactin 2 [ Mus musculus (house mouse) ]

Gene ID: 21367, updated on 12-Jun-2018
Official Symbol
Cntn2provided by MGI
Official Full Name
contactin 2provided by MGI
Primary source
MGI:MGI:104518
See related
Ensembl:ENSMUSG00000053024 Vega:OTTMUSG00000049393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tax; TAG1; TAG-1; D130012K04Rik
Summary
This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. Mice lacking a functional copy of this gene exhibit epileptic seizures and elevated expression of A1 adenosine receptors. [provided by RefSeq, Sep 2016]
Expression
Biased expression in cerebellum adult (RPKM 27.9), CNS E14 (RPKM 19.9) and 5 other tissues See more
Orthologs
See Cntn2 in Genome Data Viewer
Location:
1; 1 E4
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (132509425..132543251, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (134406002..134439517, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene dual serine/threonine and tyrosine protein kinase Neighboring gene retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit Neighboring gene transmembrane protein 81 Neighboring gene neurofascin Neighboring gene predicted gene, 46157 Neighboring gene predicted gene 10538

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein self-association IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
central nervous system myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex GABAergic interneuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
clustering of voltage-gated potassium channels IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of protein localization to juxtaparanode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of adenosine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein processing IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic membrane organization ISO
Inferred from Sequence Orthology
more info
 
protein localization to juxtaparanode region of axon IGI
Inferred from Genetic Interaction
more info
PubMed 
protein localization to juxtaparanode region of axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of axon diameter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell morphogenesis involved in differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
juxtaparanode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
node of Ranvier IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
contactin-2
Names
TAX-1
axonal glycoprotein TAG-1
axonin
axonin-1
transient axonal glycoprotein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177129.5NP_796103.2  contactin-2 precursor

    See identical proteins and their annotated locations for NP_796103.2

    Status: REVIEWED

    Source sequence(s)
    AK083808, BC066106, BC079585, CJ108593
    Consensus CDS
    CCDS15288.1
    UniProtKB/Swiss-Prot
    Q61330
    Related
    ENSMUSP00000083707.4, OTTMUSP00000068144, ENSMUST00000086521.10, OTTMUST00000125915
    Conserved Domains (8) summary
    cd04968
    Location:241326
    Ig3_Contactin_like; Third Ig domain of contactin
    cd04969
    Location:435507
    Ig5_Contactin_like; Fifth Ig domain of contactin
    cd05727
    Location:133230
    Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
    cd05728
    Location:330414
    Ig4_Contactin-2-like; Fourth Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
    smart00410
    Location:248325
    IG_like; Immunoglobulin like
    cd00063
    Location:817909
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:329414
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:38131
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    132509425..132543251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529362.2XP_006529425.1  contactin-2 isoform X1

    See identical proteins and their annotated locations for XP_006529425.1

    UniProtKB/Swiss-Prot
    Q61330
    Conserved Domains (8) summary
    cd04968
    Location:241326
    Ig3_Contactin_like; Third Ig domain of contactin
    cd04969
    Location:435507
    Ig5_Contactin_like; Fifth Ig domain of contactin
    cd05727
    Location:133230
    Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
    cd05728
    Location:330414
    Ig4_Contactin-2-like; Fourth Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
    smart00410
    Location:248325
    IG_like; Immunoglobulin like
    cd00063
    Location:817909
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:329414
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:38131
    Ig; Immunoglobulin domain

RNA

  1. XR_878318.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011531.3: Suppressed sequence

    Description
    NM_011531.3: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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