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Arhgef19 Rho guanine nucleotide exchange factor 19 [ Mus musculus (house mouse) ]

Gene ID: 213649, updated on 5-Mar-2024

Summary

Official Symbol
Arhgef19provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 19provided by MGI
Primary source
MGI:MGI:1925912
See related
Ensembl:ENSMUSG00000028919 AllianceGenome:MGI:1925912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
WGEF; 6030432F23; 6430573B13Rik
Summary
Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within positive regulation of GTPase activity and wound healing. Is expressed in several structures, including genitourinary system; nose; oral epithelium; pharyngo-tympanic tube; and vibrissa. Orthologous to human ARHGEF19 (Rho guanine nucleotide exchange factor 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 12.6), duodenum adult (RPKM 12.6) and 19 other tissues See more
Orthologs
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Genomic context

See Arhgef19 in Genome Data Viewer
Location:
4 D3; 4 73.53 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140966916..140985226)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141239605..141257915)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3534 Neighboring gene F-box protein 42 Neighboring gene STARR-seq mESC enhancer starr_11892 Neighboring gene STARR-positive B cell enhancer ABC_E10273 Neighboring gene STARR-positive B cell enhancer ABC_E3535 Neighboring gene STARR-positive B cell enhancer ABC_E6249 Neighboring gene ciliogenesis and planar polarity effector 2 Neighboring gene RIKEN cDNA C630004L07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr4:140795314-140795615 Neighboring gene predicted gene, 52686 Neighboring gene STARR-seq mESC enhancer starr_11896 Neighboring gene STARR-seq mESC enhancer starr_11899 Neighboring gene predicted gene 13056 Neighboring gene STARR-seq mESC enhancer starr_11901 Neighboring gene Eph receptor A2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
rho guanine nucleotide exchange factor 19
Names
Rho guanine nucleotide exchange factor (GEF) 19
ephexin-2
weakly similar to Rho GEF 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379647.1NP_001366576.1  rho guanine nucleotide exchange factor 19

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AL607087
    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719773
    SH3; Src Homology 3 domain superfamily
  2. NM_001379652.1NP_001366581.1  rho guanine nucleotide exchange factor 19

    Status: VALIDATED

    Source sequence(s)
    AL607087
    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719773
    SH3; Src Homology 3 domain superfamily
  3. NM_172520.3NP_766108.1  rho guanine nucleotide exchange factor 19

    See identical proteins and their annotated locations for NP_766108.1

    Status: VALIDATED

    Source sequence(s)
    AL607087
    Consensus CDS
    CCDS18868.1
    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Related
    ENSMUSP00000006618.3, ENSMUST00000006618.9
    Conserved Domains (3) summary
    cd01221
    Location:580706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719773
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    140966916..140985226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250225.3XP_011248527.1  rho guanine nucleotide exchange factor 19 isoform X1

    See identical proteins and their annotated locations for XP_011248527.1

    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719773
    SH3; Src Homology 3 domain superfamily
  2. XM_006538705.2XP_006538768.1  rho guanine nucleotide exchange factor 19 isoform X1

    See identical proteins and their annotated locations for XP_006538768.1

    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719773
    SH3; Src Homology 3 domain superfamily
  3. XM_017320098.1XP_017175587.1  rho guanine nucleotide exchange factor 19 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719773
    SH3; Src Homology 3 domain superfamily
  4. XM_006538709.5XP_006538772.1  rho guanine nucleotide exchange factor 19 isoform X1

    See identical proteins and their annotated locations for XP_006538772.1

    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719773
    SH3; Src Homology 3 domain superfamily
  5. XM_006538708.4XP_006538771.1  rho guanine nucleotide exchange factor 19 isoform X1

    See identical proteins and their annotated locations for XP_006538771.1

    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719773
    SH3; Src Homology 3 domain superfamily