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Dync2li1 dynein cytoplasmic 2 light intermediate chain 1 [ Mus musculus (house mouse) ]

Gene ID: 213575, updated on 11-Apr-2024

Summary

Official Symbol
Dync2li1provided by MGI
Official Full Name
dynein cytoplasmic 2 light intermediate chain 1provided by MGI
Primary source
MGI:MGI:1913996
See related
Ensembl:ENSMUSG00000024253 AllianceGenome:MGI:1913996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LIC3; D2lic; CGI-60; mD2LIC; 4933404O11Rik
Summary
Predicted to enable dynein heavy chain binding activity. Acts upstream of or within cilium assembly and determination of left/right symmetry. Located in apical part of cell; axoneme; and motile cilium. Is expressed in embryo; gut; heart; and node. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNC2LI1 (dynein cytoplasmic 2 light intermediate chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 9.3), CNS E18 (RPKM 7.9) and 19 other tissues See more
Orthologs
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Genomic context

Location:
17 E4; 17 55.02 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (84933903..84962996)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (84626475..84655568)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 Neighboring gene RIKEN cDNA 4930500A05 gene Neighboring gene predicted gene, 26066 Neighboring gene ATP binding cassette subfamily G member 5 Neighboring gene ATP binding cassette subfamily G member 8 Neighboring gene STARR-seq mESC enhancer starr_43448 Neighboring gene leucine-rich PPR-motif containing Neighboring gene STARR-seq mESC enhancer starr_43449 Neighboring gene STARR-positive B cell enhancer ABC_E3219

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC7211, MGC40646

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynein heavy chain binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytoplasmic dynein 2 light intermediate chain 1
Names
dynein 2 light intermediate chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172256.2NP_758460.1  cytoplasmic dynein 2 light intermediate chain 1

    See identical proteins and their annotated locations for NP_758460.1

    Status: VALIDATED

    Source sequence(s)
    AC132353
    Consensus CDS
    CCDS29000.1
    UniProtKB/Swiss-Prot
    Q3TVA2, Q8K0T2
    Related
    ENSMUSP00000025101.9, ENSMUST00000025101.10
    Conserved Domains (1) summary
    cl21455
    Location:37241
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    84933903..84962996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)