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Fbxo42 F-box protein 42 [ Mus musculus (house mouse) ]

Gene ID: 213499, updated on 26-Sep-2022

Summary

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Official Symbol
Fbxo42provided by MGI
Official Full Name
F-box protein 42provided by MGI
Primary source
MGI:MGI:1924992
See related
Ensembl:ENSMUSG00000028920 AllianceGenome:MGI:1924992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1332; 6720460I06Rik
Summary
Is expressed in brain; glossopharyngeal ganglion; spinal cord; trigeminal ganglion; and vestibulo-cochlear ganglion. Orthologous to human FBXO42 (F-box protein 42). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 8.6), whole brain E14.5 (RPKM 8.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxo42 in Genome Data Viewer
Location:
4; 4 D3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140875216..140931373)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141147922..141204062)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 21 Neighboring gene SUZ RNA binding domain containing 1 Neighboring gene ciliogenesis and planar polarity effector 2 Neighboring gene RIKEN cDNA C630004L07 gene Neighboring gene Rho guanine nucleotide exchange factor (GEF) 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects. Nath AK, et al. PLoS One, 2009. PMID 19156209, Free PMC Article
  2. Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous Kras(G12D). Huang J, et al. Sci Rep, 2019 Nov 20. PMID 31748650, Free PMC Article
  3. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (23) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
F-box only protein 42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172518.3 → NP_766106.2  F-box only protein 42

    See identical proteins and their annotated locations for NP_766106.2

    Status: VALIDATED

    Source sequence(s)
    BC058667, BQ177305, BY161466
    Consensus CDS
    CCDS18866.1
    UniProtKB/Swiss-Prot
    Q6PDJ6, Q99KY2
    Related
    ENSMUSP00000030757.10, ENSMUST00000030757.10
    Conserved Domains (4) summary
    sd00038
    Location:119 → 168
    Kelch; KELCH repeat [structural motif]
    pfam00906
    Location:317 → 432
    Hepatitis_core; Hepatitis core antigen
    pfam12937
    Location:47 → 82
    F-box-like; F-box-like
    pfam13415
    Location:130 → 182
    Kelch_3; Galactose oxidase, central domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    140875216..140931373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538702.5 → XP_006538765.1  F-box only protein 42 isoform X1

    Conserved Domains (6) summary
    PLN02772
    Location:189 → 276
    PLN02772; guanylate kinase
    sd00038
    Location:135 → 190
    Kelch; KELCH repeat [structural motif]
    pfam00906
    Location:278 → 393
    Hepatitis_core; Hepatitis core antigen
    pfam12937
    Location:47 → 82
    F-box-like
    pfam13854
    Location:190 → 229
    Kelch_5; Kelch motif
    pfam13415
    Location:91 → 143
    Kelch_3; Galactose oxidase, central domain

  2. XM_006538703.5 → XP_006538766.1  F-box only protein 42 isoform X2

    Conserved Domains (5) summary
    PLN02772
    Location:96 → 183
    PLN02772; guanylate kinase
    sd00038
    Location:42 → 97
    Kelch; KELCH repeat [structural motif]
    pfam00906
    Location:185 → 300
    Hepatitis_core; Hepatitis core antigen
    pfam13854
    Location:97 → 136
    Kelch_5; Kelch motif
    pfam13415
    Location:1 → 50
    Kelch_3; Galactose oxidase, central domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDJ6.1 GenPept UniProtKB/Swiss-Prot:Q6PDJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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