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Tagln transgelin [ Mus musculus (house mouse) ]

Gene ID: 21345, updated on 1-Oct-2024

Summary

Official Symbol
Taglnprovided by MGI
Official Full Name
transgelinprovided by MGI
Primary source
MGI:MGI:106012
See related
Ensembl:ENSMUSG00000032085 AllianceGenome:MGI:106012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sm22; Sm22a; Ws310
Summary
This gene encodes a smooth muscle cell-specific cytoskeletal protein. The encoded protein is structurally similar to calponin, an actin-binding protein. In mouse models of atherosclerosis the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis. [provided by RefSeq, Mar 2010]
Expression
Biased expression in bladder adult (RPKM 3112.1), stomach adult (RPKM 1002.7) and 5 other tissues See more
Orthologs
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Genomic context

See Tagln in Genome Data Viewer
Location:
9 A5.2; 9 25.36 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45840926..45847356, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45929628..45936058, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45655339-45655522 Neighboring gene beta-site APP cleaving enzyme 1 Neighboring gene ring finger protein 214 Neighboring gene predicted gene, 24646 Neighboring gene STARR-seq mESC enhancer starr_24009 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene microRNA 7087 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene RIKEN cDNA A830035O19 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (6)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
NOT acts_upstream_of_or_within cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transgelin
Names
SM22-alpha
Sm22alpha
actin-associated protein p27
smooth muscle protein 22-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011526.5NP_035656.1  transgelin

    See identical proteins and their annotated locations for NP_035656.1

    Status: REVIEWED

    Source sequence(s)
    AC122273, AK077235
    Consensus CDS
    CCDS23137.1
    UniProtKB/Swiss-Prot
    P37804, Q545W0
    Related
    ENSMUSP00000034590.3, ENSMUST00000034590.4
    Conserved Domains (3) summary
    COG5199
    Location:14189
    SCP1; Calponin [Cytoskeleton]
    cd00014
    Location:25137
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00402
    Location:175198
    Calponin; Calponin family repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45840926..45847356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)