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Gpr174 G protein-coupled receptor 174 [ Mus musculus (house mouse) ]

Gene ID: 213439, updated on 9-Mar-2023

Summary

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Official Symbol
Gpr174provided by MGI
Official Full Name
G protein-coupled receptor 174provided by MGI
Primary source
MGI:MGI:2685222
See related
Ensembl:ENSMUSG00000073008 AllianceGenome:MGI:2685222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm376; Lypsr3
Summary
Enables bioactive lipid receptor activity. Acts upstream of or within T cell homeostasis. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human GPR174 (G protein-coupled receptor 174). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Gpr174 in Genome Data Viewer
Location:
X; X D
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (106299484..106340377)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (107255878..107296771)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2Y, G-protein coupled 10B Neighboring gene prohibitin pseudogene Neighboring gene alpha-enolase pseudogene Neighboring gene glutamate dehydrogenase 1 pseudogene Neighboring gene ribosomal protein L7a pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression. Liu J, et al. Nat Commun, 2022 Dec 6. PMID 36473866, Free PMC Article
  2. GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells. Wolf EW, et al. Proc Natl Acad Sci U S A, 2022 Jun 7. PMID 35639700, Free PMC Article
  3. GPR174 suppression attenuates retinopathy in angiotensin II (Ang II)-treated mice by reducing inflammation via PI3K/AKT signaling. Yue J, et al. Biomed Pharmacother, 2020 Feb. PMID 31918274
  4. The increased marginal zone B cells attenuates early inflammatory responses during sepsis in Gpr174 deficient mice. Zhu M, et al. Int Immunopharmacol, 2020 Apr. PMID 31786099
  5. Gpr174-deficient regulatory T cells decrease cytokine storm in septic mice. Qiu D, et al. Cell Death Dis, 2019 Mar 8. PMID 30850582, Free PMC Article

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression.
    Title: GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression.
  2. GPR174 signals via Galphas to control a CD86-containing gene expression program in B cells.
    Title: GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells.
  3. GPR174 mRNA Acts as a Novel Prognostic Biomarker for Patients With Sepsis via Regulating the Inflammatory Response.
    Title: GPR174 mRNA Acts as a Novel Prognostic Biomarker for Patients With Sepsis via Regulating the Inflammatory Response.
  4. The increased marginal zone B cells attenuates early inflammatory responses during sepsis in Gpr174 deficient mice.
    Title: The increased marginal zone B cells attenuates early inflammatory responses during sepsis in Gpr174 deficient mice.
  5. GPR174 suppression attenuates retinopathy in angiotensin II (Ang II)-treated mice by reducing inflammation via PI3K/AKT signaling.
    Title: GPR174 suppression attenuates retinopathy in angiotensin II (Ang II)-treated mice by reducing inflammation via PI3K/AKT signaling.
  6. the findings suggested that GPR174 plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions.
    Title: Gpr174-deficient regulatory T cells decrease cytokine storm in septic mice.
  7. By identifying GPR174 as a receptor for CCL21 and demonstrating its sex-dependent control of B-cell positioning and participation in germinal centres, we have revealed a mechanism by which B-cell physiology is fine-tuned to impart sexual dimorphism to humoral immunity
    Title: A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity.
  8. Lysophosphatidyl serine acts via GPR174 and Galphas to suppress IL-2 production by activated T cells
    Title: Lysophosphatidylserine suppression of T-cell activation via GPR174 requires Gαs proteins.
  9. The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.
    Title: The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables bioactive lipid receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 174
Names
putative purinergic receptor FKSG79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033251.5 → NP_001028423.1  probable G-protein coupled receptor 174

    See identical proteins and their annotated locations for NP_001028423.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. An upstream AUG is present that would result in a 13 aa N-terminal extension, but it has a weak Kozak signal and is absent in other mammals, whereas the annotated dAUG has a stronger Kozak signal and is well-conserved among mammals.
    Source sequence(s)
    AK153611, AL663081
    Consensus CDS
    CCDS30348.1
    UniProtKB/Swiss-Prot
    Q3U507
    Related
    ENSMUSP00000112974.2, ENSMUST00000120971.8
    Conserved Domains (1) summary
    cd15152
    Location:20 → 303
    7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001177781.1 → NP_001171252.1  probable G-protein coupled receptor 174

    See identical proteins and their annotated locations for NP_001171252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein. An upstream AUG is present that would result in a 13 aa N-terminal extension, but it has a weak Kozak signal and is absent in other mammals, whereas the annotated dAUG has a stronger Kozak signal and is well-conserved among mammals.
    Source sequence(s)
    AL663081
    Consensus CDS
    CCDS30348.1
    UniProtKB/Swiss-Prot
    Q3U507
    Related
    ENSMUSP00000098852.3, ENSMUST00000101294.9
    Conserved Domains (1) summary
    cd15152
    Location:20 → 303
    7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001177782.1 → NP_001171253.1  probable G-protein coupled receptor 174

    See identical proteins and their annotated locations for NP_001171253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. An upstream AUG is present that would result in a 13 aa N-terminal extension, but it has a weak Kozak signal and is absent in other mammals, whereas the annotated dAUG has a stronger Kozak signal and is well-conserved among mammals.
    Source sequence(s)
    AL663081, BQ562837
    Consensus CDS
    CCDS30348.1
    UniProtKB/Swiss-Prot
    Q3U507
    Related
    ENSMUSP00000137372.2, ENSMUST00000178838.2
    Conserved Domains (1) summary
    cd15152
    Location:20 → 303
    7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001358747.1 → NP_001345676.1  probable G-protein coupled receptor 174

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. An upstream AUG is present that would result in a 13 aa N-terminal extension, but it has a weak Kozak signal and is absent in other mammals, whereas the annotated dAUG has a stronger Kozak signal and is well-conserved among mammals.
    Source sequence(s)
    AL663081
    Consensus CDS
    CCDS30348.1
    UniProtKB/Swiss-Prot
    Q3U507
    Related
    ENSMUSP00000113032.2, ENSMUST00000118820.8
    Conserved Domains (1) summary
    cd15152
    Location:20 → 303
    7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    106299484..106340377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318457.2 → XP_017173946.1  probable G-protein coupled receptor 174 isoform X1

    Conserved Domains (1) summary
    cd15152
    Location:33 → 316
    7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U507.1 GenPept UniProtKB/Swiss-Prot:Q3U507

Gene LinkOut

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