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Tacc3 transforming, acidic coiled-coil containing protein 3 [ Mus musculus (house mouse) ]

Gene ID: 21335, updated on 21-Apr-2024

Summary

Official Symbol
Tacc3provided by MGI
Official Full Name
transforming, acidic coiled-coil containing protein 3provided by MGI
Primary source
MGI:MGI:1341163
See related
Ensembl:ENSMUSG00000037313 AllianceGenome:MGI:1341163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aint; Eric1
Summary
Enables protein domain specific binding activity. Acts upstream of or within several processes, including astral microtubule organization; cytoplasmic sequestering of transcription factor; and nervous system development. Located in centrosome and cytoplasm. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Orthologous to human TACC3 (transforming acidic coiled-coil containing protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 34.6), liver E14 (RPKM 25.7) and 18 other tissues See more
Orthologs
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Genomic context

Location:
5 B2; 5 17.83 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33814808..33836331)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33658128..33672203)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6317 Neighboring gene predicted gene 9903 Neighboring gene STARR-positive B cell enhancer ABC_E6318 Neighboring gene stem-loop binding protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34000710-34000897 Neighboring gene predicted gene 10459 Neighboring gene transmembrane protein 129 Neighboring gene STARR-seq mESC enhancer starr_12827 Neighboring gene Fgfr3 5' regulatory region Neighboring gene fibroblast growth factor receptor 3 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_12830 Neighboring gene ribosomal protein S29 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within astral microtubule organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cytoplasmic sequestering of transcription factor IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within interkinetic nuclear migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metaphase/anaphase transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule cytoskeleton organization involved in mitosis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
PubMed 

General protein information

Preferred Names
transforming acidic coiled-coil-containing protein 3
Names
ARNT-interacting protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040435.4NP_001035525.1  transforming acidic coiled-coil-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001035525.1

    Status: VALIDATED

    Source sequence(s)
    AC162898
    Consensus CDS
    CCDS39065.1
    UniProtKB/TrEMBL
    Q6NV52, Q9JIQ5
    Related
    ENSMUSP00000110069.4, ENSMUST00000114426.10
    Conserved Domains (2) summary
    pfam05010
    Location:428624
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl03075
    Location:426580
    GrpE; nucleotide exchange factor GrpE
  2. NM_001310541.2NP_001297470.1  transforming acidic coiled-coil-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001297470.1

    Status: VALIDATED

    Source sequence(s)
    AC162898
    Consensus CDS
    CCDS80258.1
    UniProtKB/TrEMBL
    Q99LH8, Q9JIQ5
    Related
    ENSMUSP00000074394.7, ENSMUST00000074849.13
    Conserved Domains (2) summary
    PRK10811
    Location:144294
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:435631
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  3. NM_001405350.1NP_001392279.1  transforming acidic coiled-coil-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC162898
  4. NM_001405351.1NP_001392280.1  transforming acidic coiled-coil-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC162898
  5. NM_001405352.1NP_001392281.1  transforming acidic coiled-coil-containing protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC162898
  6. NM_001405353.1NP_001392282.1  transforming acidic coiled-coil-containing protein 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162898
  7. NM_001405354.1NP_001392283.1  transforming acidic coiled-coil-containing protein 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162898
  8. NM_001405355.1NP_001392284.1  transforming acidic coiled-coil-containing protein 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC162898
  9. NM_001405356.1NP_001392285.1  transforming acidic coiled-coil-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162898
    UniProtKB/TrEMBL
    Q6NV52
    Related
    ENSMUSP00000078491.5, ENSMUST00000079534.11
  10. NM_001405357.1NP_001392286.1  transforming acidic coiled-coil-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162898
    UniProtKB/TrEMBL
    Q6NV52
  11. NM_001405358.1NP_001392287.1  transforming acidic coiled-coil-containing protein 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC162898
  12. NM_001405360.1NP_001392289.1  transforming acidic coiled-coil-containing protein 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC162898

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    33814808..33836331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254350.2XP_030110210.1  transforming acidic coiled-coil-containing protein 3 isoform X6

    UniProtKB/TrEMBL
    Q9JIQ5
    Conserved Domains (2) summary
    PRK10811
    Location:144294
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:428569
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  2. XM_030254352.2XP_030110212.1  transforming acidic coiled-coil-containing protein 3 isoform X9

    Conserved Domains (2) summary
    PRK10811
    Location:71221
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:355496
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  3. XM_030254349.2XP_030110209.1  transforming acidic coiled-coil-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    Q9JIQ5
    Conserved Domains (3) summary
    PRK10263
    Location:23274
    PRK10263; DNA translocase FtsK; Provisional
    PRK10811
    Location:160310
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:444626
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  4. XM_006503835.5XP_006503898.1  transforming acidic coiled-coil-containing protein 3 isoform X7

    UniProtKB/TrEMBL
    Q9JIQ5
    Conserved Domains (2) summary
    PRK10811
    Location:71221
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:362558
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  5. XM_011240716.4XP_011239018.1  transforming acidic coiled-coil-containing protein 3 isoform X4

    UniProtKB/TrEMBL
    Q9JIQ5
    Conserved Domains (3) summary
    PRK10263
    Location:23274
    PRK10263; DNA translocase FtsK; Provisional
    PRK10811
    Location:160310
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:451592
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  6. XM_011240715.1XP_011239017.1  transforming acidic coiled-coil-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    Q9JIQ5
    Conserved Domains (3) summary
    PRK10263
    Location:23274
    PRK10263; DNA translocase FtsK; Provisional
    PRK10811
    Location:160310
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:444640
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  7. XM_036164983.1XP_036020876.1  transforming acidic coiled-coil-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    Q9JIQ5
    Conserved Domains (3) summary
    PRK10263
    Location:23274
    PRK10263; DNA translocase FtsK; Provisional
    PRK10811
    Location:160310
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:444583
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  8. XM_006503832.4XP_006503895.1  transforming acidic coiled-coil-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006503895.1

    UniProtKB/TrEMBL
    Q99LH8, Q9JIQ5
    Conserved Domains (2) summary
    PRK10811
    Location:144294
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:435631
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

RNA

  1. XR_868281.4 RNA Sequence

  2. XR_003955613.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011524.3: Suppressed sequence

    Description
    NM_011524.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.