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Tac2 tachykinin 2 [ Mus musculus (house mouse) ]

Gene ID: 21334, updated on 14-Oct-2021

Summary

Official Symbol
Tac2provided by MGI
Official Full Name
tachykinin 2provided by MGI
Primary source
MGI:MGI:98476
See related
Ensembl:ENSMUSG00000025400
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tac3; PPT-B
Summary
This gene encodes a member of the tachykinin family of signaling peptides that is widely expressed in the central nervous system and plays a role in diverse processes such as water homeostasis, pulmonary inflammation, cognition, fear memory consolidation and preeclampsia. The encoded protein is enzymatically processed to generate the mature neuropeptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Biased expression in liver E14.5 (RPKM 9.9), liver E14 (RPKM 8.0) and 9 other tissues See more
Orthologs
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Genomic context

See Tac2 in Genome Data Viewer
Location:
10; 10 D3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127560347..127567637)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127724478..127731768)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127162448..127168824)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene nuclear envelope integral membrane protein 1 Neighboring gene myosin IA Neighboring gene zinc finger and BTB domain containing 39 Neighboring gene G protein-coupled receptor 182

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neuromedin K receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables substance K receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
 
involved_in tachykinin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tachykinin-3
Names
neurokinin 2
neurokinin A
neurokinin B-like protein Zneurok1
neurokinin alpha
neuromedin L
neuropeptide K
preprotachykinin-B
substance K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199971.1NP_001186900.1  tachykinin-3 preproprotein

    See identical proteins and their annotated locations for NP_001186900.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC160970, BC031348
    Consensus CDS
    CCDS24248.1
    UniProtKB/Swiss-Prot
    P55099
    Related
    ENSMUSP00000136622.2, ENSMUST00000179960.8
    Conserved Domains (1) summary
    pfam03823
    Location:153
    Neurokinin_B; Neurokinin B
  2. NM_009312.2NP_033338.2  tachykinin-3 preproprotein

    See identical proteins and their annotated locations for NP_033338.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC160970, BC031348
    Consensus CDS
    CCDS24248.1
    UniProtKB/Swiss-Prot
    P55099
    Related
    ENSMUSP00000026466.4, ENSMUST00000026466.5
    Conserved Domains (1) summary
    pfam03823
    Location:153
    Neurokinin_B; Neurokinin B

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127560347..127567637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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