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Tac1 tachykinin 1 [ Mus musculus (house mouse) ]

Gene ID: 21333, updated on 10-Jan-2023

Summary

Official Symbol
Tac1provided by MGI
Official Full Name
tachykinin 1provided by MGI
Primary source
MGI:MGI:98474
See related
Ensembl:ENSMUSG00000061762 AllianceGenome:MGI:98474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SP; NK1; NK-1; Nkna; PPTA; PPT-A; 4930528L02Rik
Summary
Predicted to enable neurokinin receptor binding activity and receptor ligand activity. Acts upstream of or within several processes, including cellular response to nerve growth factor stimulus; response to pain; and sensory perception of pain. Located in axon; extracellular region; and neuronal cell body. Is expressed in several structures, including alimentary system; integumental system; limb; nervous system; and sensory organ. Orthologous to human TAC1 (tachykinin precursor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 16.9), whole brain E14.5 (RPKM 7.7) and 8 other tissues See more
Orthologs
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Genomic context

See Tac1 in Genome Data Viewer
Location:
6 A1; 6 3.31 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (7555061..7562978)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (7555061..7562978)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene centromere protein E pseudogene Neighboring gene predicted gene, 19272 Neighboring gene predicted gene, 35051 Neighboring gene SET pseudogene Neighboring gene asparagine synthetase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC151458

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neuromedin K receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables substance K receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables substance P receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antifungal humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in associative learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to nerve growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of temperature stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of corticosterone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lymphocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of saliva secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to yeast ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tachykinin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protachykinin-1
Names
neurokinin 1
neurokinin A
preprotachykinin A
substance P

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311060.2NP_001297989.1  protachykinin-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001297989.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AI835507, AI837972, CJ059943, CX238160
    Consensus CDS
    CCDS80486.1
    UniProtKB/TrEMBL
    A0A6P5PW52, A0A8C6MT92, B7ZMQ2
    Related
    ENSMUSP00000138818.2, ENSMUST00000184986.2
  2. NM_009311.3NP_033337.1  protachykinin-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033337.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC132117
    Consensus CDS
    CCDS19906.1
    UniProtKB/Swiss-Prot
    P41539, Q00073
    UniProtKB/TrEMBL
    A0A6P5PRT1, A0A8C6GSJ1, Q149W7
    Related
    ENSMUSP00000139347.2, ENSMUST00000185187.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    7555061..7562978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505027.1XP_006505090.1  protachykinin-1 isoform X1

    See identical proteins and their annotated locations for XP_006505090.1

    UniProtKB/Swiss-Prot
    P41539, Q00073
    UniProtKB/TrEMBL
    A0A6P5PRT1, A0A8C6GSJ1, Q149W7