Format

Send to:

Choose Destination

Txndc2 thioredoxin domain containing 2 (spermatozoa) [ Mus musculus (house mouse) ]

Gene ID: 213272, updated on 12-Aug-2019

Summary

Official Symbol
Txndc2provided by MGI
Official Full Name
thioredoxin domain containing 2 (spermatozoa)provided by MGI
Primary source
MGI:MGI:2389312
See related
Ensembl:ENSMUSG00000050612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trx4; Sptrx1; Sptrx-1; AU021712
Expression
Restricted expression toward testis adult (RPKM 67.4) See more
Orthologs

Genomic context

See Txndc2 in Genome Data Viewer
Location:
17; 17 E1.1
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65637505..65648874, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (65986845..65991544, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene vesicle-associated membrane protein, associated protein A Neighboring gene predicted gene, 35477 Neighboring gene RAB31, member RAS oncogene family Neighboring gene protein phosphatase 4, regulatory subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein disulfide isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
thioredoxin-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular response to reactive oxygen species IGI
Inferred from Genetic Interaction
more info
PubMed 
flagellated sperm motility IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
outer dense fiber ISO
Inferred from Sequence Orthology
more info
 
sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thioredoxin domain-containing protein 2
Names
spermatid-specific thioredoxin 1
thioredoxin-4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146002.1NP_001139474.1  thioredoxin domain-containing protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AV272934, BC060981, BU938074
    Consensus CDS
    CCDS50165.1
    UniProtKB/Swiss-Prot
    Q6P902
    UniProtKB/TrEMBL
    H7BX21
    Related
    ENSMUSP00000054909.5, ENSMUST00000050236.6
    Conserved Domains (1) summary
    cd02947
    Location:454546
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
  2. NM_153519.2NP_705739.2  thioredoxin domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_705739.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AF196282, AV272934
    UniProtKB/Swiss-Prot
    Q6P902
    Related
    ENSMUSP00000156697.1, ENSMUST00000233702.1
    Conserved Domains (1) summary
    cd02947
    Location:447539
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p6 C57BL/6J

    Range
    65637505..65648874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246354.3XP_011244656.1  thioredoxin domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011244656.1

    Conserved Domains (1) summary
    cd02947
    Location:447539
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
  2. XM_030249623.1XP_030105483.1  thioredoxin domain-containing protein 2 isoform X1

  3. XM_006523986.3XP_006524049.1  thioredoxin domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006524049.1

    Conserved Domains (1) summary
    cd02947
    Location:447539
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
Support Center