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Dnd1 DND microRNA-mediated repression inhibitor 1 [ Mus musculus (house mouse) ]

Gene ID: 213236, updated on 5-Mar-2024

Summary

Official Symbol
Dnd1provided by MGI
Official Full Name
DND microRNA-mediated repression inhibitor 1provided by MGI
Primary source
MGI:MGI:2447763
See related
Ensembl:ENSMUSG00000044595 AllianceGenome:MGI:2447763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ter; RBMS4
Summary
Predicted to enable mRNA 3'-UTR binding activity. Acts upstream of or within germ cell development. Located in cytoplasm. Is expressed in several structures, including allantois; central nervous system; gonad; head mesenchyme; and sensory organ. Orthologous to human DND1 (DND microRNA-mediated repression inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 10.8), ovary adult (RPKM 7.1) and 28 other tissues See more
Orthologs
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Genomic context

See Dnd1 in Genome Data Viewer
Location:
18 B2; 18 19.46 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36896724..36899267, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36763671..36766214, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 6 Neighboring gene STARR-positive B cell enhancer ABC_E617 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2 Neighboring gene IK cytokine Neighboring gene WD repeat domain 55 Neighboring gene histidyl-tRNA synthetase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8710 Neighboring gene histidyl-tRNA synthetase 2 Neighboring gene STARR-positive B cell enhancer ABC_E3227 Neighboring gene zinc finger, matrin type 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC41452

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of miRNA-mediated gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of miRNA-mediated gene silencing ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dead end protein homolog 1
Names
RNA-binding motif, single-stranded-interacting protein 4
dead end homolog 1
teratoma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173383.2NP_775559.2  dead end protein homolog 1

    See identical proteins and their annotated locations for NP_775559.2

    Status: VALIDATED

    Source sequence(s)
    AY321066, BC034897
    Consensus CDS
    CCDS29163.2
    UniProtKB/Swiss-Prot
    Q6VY05, Q8CFK7
    Related
    ENSMUSP00000054412.8, ENSMUST00000061522.8
    Conserved Domains (3) summary
    cd12487
    Location:57134
    RRM1_DND1; RNA recognition motif 1 found in vertebrate dead end protein homolog 1 (DND1)
    pfam14709
    Location:253333
    DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1
    cl17169
    Location:136218
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36896724..36899267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)