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Cdkl3 cyclin-dependent kinase-like 3 [ Mus musculus (house mouse) ]

Gene ID: 213084, updated on 14-Aug-2019

Summary

Official Symbol
Cdkl3provided by MGI
Official Full Name
cyclin-dependent kinase-like 3provided by MGI
Primary source
MGI:MGI:2388268
See related
Ensembl:ENSMUSG00000020389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI852479; B230379H01Rik
Expression
Biased expression in testis adult (RPKM 12.9), CNS E18 (RPKM 1.4) and 5 other tissues See more
Orthologs

Genomic context

See Cdkl3 in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
23
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52000842..52089778)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (51817723..51898169)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene ubiquitin-conjugating enzyme E2B Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Neighboring gene predicted gene, 30631 Neighboring gene microRNA 3061

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

Markers

Homology

Clone Names

  • MGC28957

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
dendrite extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite extension ISO
Inferred from Sequence Orthology
more info
 
negative regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase-like 3
NP_001160125.1
NP_001160126.1
NP_001160127.1
NP_001160128.1
NP_001160129.1
NP_001350405.1
NP_722480.3
XP_006532830.1
XP_006532831.1
XP_006532832.1
XP_006532833.1
XP_006532835.1
XP_006532836.1
XP_011247164.1
XP_011247165.1
XP_011247167.1
XP_011247168.1
XP_011247170.1
XP_011247171.1
XP_011247172.1
XP_011247173.1
XP_011247174.1
XP_011247176.1
XP_011247179.1
XP_011247180.1
XP_011247182.1
XP_011247183.1
XP_011247184.1
XP_030101618.1
XP_030101619.1
XP_030101620.1
XP_030101621.1
XP_030101622.1
XP_030101623.1
XP_030101624.1
XP_030101625.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166653.1NP_001160125.1  cyclin-dependent kinase-like 3 isoform 1

    See identical proteins and their annotated locations for NP_001160125.1

    Status: VALIDATED

    Source sequence(s)
    AK045356, AK046394, AK050990, BB759970
    Consensus CDS
    CCDS48789.1
    UniProtKB/Swiss-Prot
    Q8BLF2
    UniProtKB/TrEMBL
    B1AU43
    Related
    ENSMUSP00000104708.2, ENSMUST00000109080.8
    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001166654.1NP_001160126.1  cyclin-dependent kinase-like 3 isoform 3

    See identical proteins and their annotated locations for NP_001160126.1

    Status: VALIDATED

    Source sequence(s)
    AK046394, AL669920
    Consensus CDS
    CCDS48790.1
    UniProtKB/Swiss-Prot
    Q8BLF2
    Related
    ENSMUSP00000112477.1, ENSMUST00000121591.7
    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001166655.1NP_001160127.1  cyclin-dependent kinase-like 3 isoform 4

    See identical proteins and their annotated locations for NP_001160127.1

    Status: VALIDATED

    Source sequence(s)
    AK046394, AK050990
    Consensus CDS
    CCDS48791.1
    UniProtKB/Swiss-Prot
    Q8BLF2
    Related
    ENSMUSP00000104706.1, ENSMUST00000109078.7
    Conserved Domains (1) summary
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001166656.1NP_001160128.1  cyclin-dependent kinase-like 3 isoform 5

    See identical proteins and their annotated locations for NP_001160128.1

    Status: VALIDATED

    Source sequence(s)
    AK046394, AK050990, AK078804
    Consensus CDS
    CCDS48788.1
    UniProtKB/Swiss-Prot
    Q8BLF2
    Related
    ENSMUSP00000065128.6, ENSMUST00000063321.12
    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001166657.1NP_001160129.1  cyclin-dependent kinase-like 3 isoform 6

    See identical proteins and their annotated locations for NP_001160129.1

    Status: VALIDATED

    Source sequence(s)
    AK046394, AK050990
    Consensus CDS
    CCDS48792.1
    UniProtKB/Swiss-Prot
    Q8BLF2
    Related
    ENSMUSP00000104704.1, ENSMUST00000109076.1
    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001363476.1NP_001350405.1  cyclin-dependent kinase-like 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669920
    Conserved Domains (1) summary
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  7. NM_153785.4NP_722480.3  cyclin-dependent kinase-like 3 isoform 2

    See identical proteins and their annotated locations for NP_722480.3

    Status: VALIDATED

    Source sequence(s)
    AK045356, AK046394, AL669920
    Consensus CDS
    CCDS24665.1
    UniProtKB/Swiss-Prot
    Q8BLF2
    Related
    ENSMUSP00000064315.4, ENSMUST00000063303.10
    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_156698.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL669920, AL935177

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    52000842..52089778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532773.3XP_006532836.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006532836.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006532772.3XP_006532835.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006532835.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011248868.3XP_011247170.1  cyclin-dependent kinase-like 3 isoform X3

    See identical proteins and their annotated locations for XP_011247170.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011248862.2XP_011247164.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_011247164.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  5. XM_011248863.3XP_011247165.1  cyclin-dependent kinase-like 3 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011248878.1XP_011247180.1  cyclin-dependent kinase-like 3 isoform X9

    See identical proteins and their annotated locations for XP_011247180.1

    UniProtKB/Swiss-Prot
    Q8BLF2
    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  7. XM_030245762.1XP_030101622.1  cyclin-dependent kinase-like 3 isoform X10

  8. XM_011248874.2XP_011247176.1  cyclin-dependent kinase-like 3 isoform X6

    See identical proteins and their annotated locations for XP_011247176.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  9. XM_030245758.1XP_030101618.1  cyclin-dependent kinase-like 3 isoform X7

  10. XM_006532768.2XP_006532831.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006532831.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  11. XM_006532767.4XP_006532830.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006532830.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  12. XM_030245764.1XP_030101624.1  cyclin-dependent kinase-like 3 isoform X9

    Related
    ENSMUSP00000104709.2, ENSMUST00000109081.8
  13. XM_006532770.2XP_006532833.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006532833.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  14. XM_006532769.4XP_006532832.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006532832.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  15. XM_030245760.1XP_030101620.1  cyclin-dependent kinase-like 3 isoform X9

  16. XM_011248881.2XP_011247183.1  cyclin-dependent kinase-like 3 isoform X10

    See identical proteins and their annotated locations for XP_011247183.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  17. XM_030245761.1XP_030101621.1  cyclin-dependent kinase-like 3 isoform X10

  18. XM_011248866.3XP_011247168.1  cyclin-dependent kinase-like 3 isoform X3

    See identical proteins and their annotated locations for XP_011247168.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  19. XM_011248871.3XP_011247173.1  cyclin-dependent kinase-like 3 isoform X4

    See identical proteins and their annotated locations for XP_011247173.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  20. XM_011248870.3XP_011247172.1  cyclin-dependent kinase-like 3 isoform X4

    See identical proteins and their annotated locations for XP_011247172.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  21. XM_011248865.3XP_011247167.1  cyclin-dependent kinase-like 3 isoform X3

    See identical proteins and their annotated locations for XP_011247167.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  22. XM_011248877.3XP_011247179.1  cyclin-dependent kinase-like 3 isoform X9

    See identical proteins and their annotated locations for XP_011247179.1

    UniProtKB/Swiss-Prot
    Q8BLF2
    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  23. XM_011248882.2XP_011247184.1  cyclin-dependent kinase-like 3 isoform X10

    See identical proteins and their annotated locations for XP_011247184.1

    Related
    ENSMUSP00000123279.1, ENSMUST00000143228.7
    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  24. XM_030245765.1XP_030101625.1  cyclin-dependent kinase-like 3 isoform X11

  25. XM_011248869.3XP_011247171.1  cyclin-dependent kinase-like 3 isoform X3

    See identical proteins and their annotated locations for XP_011247171.1

    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  26. XM_011248880.3XP_011247182.1  cyclin-dependent kinase-like 3 isoform X9

    See identical proteins and their annotated locations for XP_011247182.1

    UniProtKB/Swiss-Prot
    Q8BLF2
    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  27. XM_011248872.3XP_011247174.1  cyclin-dependent kinase-like 3 isoform X5

    See identical proteins and their annotated locations for XP_011247174.1

    UniProtKB/TrEMBL
    B1AU43
    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2286
    PKc_like; Protein Kinases, catalytic domain
  28. XM_030245759.1XP_030101619.1  cyclin-dependent kinase-like 3 isoform X8

  29. XM_030245763.1XP_030101623.1  cyclin-dependent kinase-like 3 isoform X8

RNA

  1. XR_003949370.1 RNA Sequence

  2. XR_879551.2 RNA Sequence

  3. XR_003949376.1 RNA Sequence

  4. XR_003949372.1 RNA Sequence

  5. XR_879548.1 RNA Sequence

  6. XR_879549.1 RNA Sequence

  7. XR_003949373.1 RNA Sequence

  8. XR_879545.1 RNA Sequence

  9. XR_879546.1 RNA Sequence

  10. XR_003949371.1 RNA Sequence

  11. XR_003949374.1 RNA Sequence

  12. XR_003949379.1 RNA Sequence

  13. XR_003949377.1 RNA Sequence

  14. XR_003949375.1 RNA Sequence

  15. XR_003949378.1 RNA Sequence

  16. XR_879553.1 RNA Sequence

  17. XR_879554.2 RNA Sequence

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