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ALB albumin [ Homo sapiens (human) ]

Gene ID: 213, updated on 1-Aug-2020

Summary

Official Symbol
ALBprovided by HGNC
Official Full Name
albuminprovided by HGNC
Primary source
HGNC:HGNC:399
See related
Ensembl:ENSG00000163631 MIM:103600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSA; PRO0883; PRO0903; PRO1341
Summary
This gene encodes the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones, fatty acids, and metabolites, as well as exogenous drugs. Additionally, this protein exhibits an esterase-like activity with broad substrate specificity. The encoded preproprotein is proteolytically processed to generate the mature protein. A peptide derived from this protein, EPI-X4, is an endogenous inhibitor of the CXCR4 chemokine receptor. [provided by RefSeq, Jul 2016]
Expression
Restricted expression toward liver (RPKM 41385.4) See more
Orthologs

Genomic context

See ALB in Genome Data Viewer
Location:
4q13.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (73404287..73421482)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (74269972..74287129)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 17 Neighboring gene high mobility group AT-hook 1 pseudogene 2 Neighboring gene uncharacterized LOC102724832 Neighboring gene albumin (ALB) 5' regulatory region Neighboring gene alpha fetoprotein (AFP) 5' regulatory region Neighboring gene alpha fetoprotein Neighboring gene afamin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Analbuminemia
MedGen: C0878666 OMIM: 616000 GeneReviews: Not available
Compare labs
Hyperthyroxinemia, familial dysalbuminemic
MedGen: C0342185 OMIM: 615999 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Activated granulocytes and macrophages producing hypochlorite/hypochlorous acid-altered isolated proteins antithrombin III and human serum albumin bind to gp120 and inhibit viral proliferation PubMed
env Binding of 3-hydroxyphthalic anhydride-modified human serum albumin to HIV-1 gp120 or CD4 inhibits HIV-1 entry into target cells PubMed
env Inhibition of HIV-1 binding to CD4 by suramin is reversed by human albumin, suggesting that only free suramin has antiviral properties PubMed
env The negatively charged succinylated and aconitylated albumins bind to the V3 loop (amino acids 296-330) and the C-terminal part of HIV-1 gp120 and do not interact directly with the HIV chemokine receptors CXCR4 and CCR5 PubMed
env The inhibition of HIV-1 gp120 binding to cells by succinylated human serum albumin is reversed by heparin PubMed
Envelope transmembrane glycoprotein gp41 env N-terminal gp41 peptide binds as an alpha helix (residues 519-536) to fatty acid sites on human serum albumin (HSA) PubMed
env The lysis of erythrocytes induced by the amino-terminal peptide (residues 519-541) of HIV-1 gp41 is blocked by anti-(518-541) IgG, dextran sulfate, and anionic albumins PubMed
Tat tat HIV-1 Tat increases albumin permeability in isolated human glomeruli PubMed
tat HIV-1 Tat induces a dose-dependent flux of albumin through endothelial cell monolayers, an effect involving Tat activation of the VEGF receptor type 2 and MAP kinase PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp779N1935

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
antioxidant activity NAS
Non-traceable Author Statement
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
copper ion binding NAS
Non-traceable Author Statement
more info
PubMed 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding NAS
Non-traceable Author Statement
more info
PubMed 
enterobactin binding IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid binding IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid binding NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to oxygen binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
toxic substance binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle remodeling TAS
Traceable Author Statement
more info
 
maintenance of mitochondrion location IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of programmed cell death NAS
Non-traceable Author Statement
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
retina homeostasis HEP PubMed 
transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
blood microparticle HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
albumin
Names
serum albumin
NP_000468.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009291.1 RefSeqGene

    Range
    5033..22228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000477.7NP_000468.1  albumin preproprotein

    See identical proteins and their annotated locations for NP_000468.1

    Status: REVIEWED

    Source sequence(s)
    AC108157, DA642320, DB186399, DQ986150, N53869
    Consensus CDS
    CCDS3555.1
    UniProtKB/Swiss-Prot
    P02768
    Related
    ENSP00000295897.4, ENST00000295897.9
    Conserved Domains (1) summary
    smart00103
    Location:404594
    ALBUMIN; serum albumin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    73404287..73421482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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