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Rsph4a radial spoke head 4 homolog A (Chlamydomonas) [ Mus musculus (house mouse) ]

Gene ID: 212892, updated on 5-Mar-2024

Summary

Official Symbol
Rsph4aprovided by MGI
Official Full Name
radial spoke head 4 homolog A (Chlamydomonas)provided by MGI
Primary source
MGI:MGI:3027894
See related
Ensembl:ENSMUSG00000039552 AllianceGenome:MGI:3027894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rshl3; A230081C05
Summary
Involved in radial spoke assembly. Acts upstream of or within maintenance of ciliary planar beating movement pattern. Located in cilium. Part of radial spoke head. Is expressed in lateral ventricle choroid plexus; lung epithelium; metencephalon part of 4th ventricle choroid plexus; and nasal cavity respiratory epithelium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 11. Orthologous to human RSPH4A (radial spoke head component 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 1.0), bladder adult (RPKM 0.7) and 12 other tissues See more
Orthologs
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Genomic context

Location:
10 B1; 10 18.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (33781107..33792017)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (33905111..33916021)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_26255 Neighboring gene sulfotransferase family 3A, member 1 Neighboring gene STARR-seq mESC enhancer starr_26256 Neighboring gene STARR-seq mESC enhancer starr_26257 Neighboring gene STARR-seq mESC enhancer starr_26258 Neighboring gene zinc finger containing ubiquitin peptidase 1 Neighboring gene predicted gene, 48018 Neighboring gene STARR-seq mESC enhancer starr_26259 Neighboring gene STARR-seq mESC enhancer starr_26260 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in 9+2 motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in axoneme ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of radial spoke IEA
Inferred from Electronic Annotation
more info
 
part_of radial spoke head IDA
Inferred from Direct Assay
more info
PubMed 
part_of radial spoke head IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of radial spoke head 1 IDA
Inferred from Direct Assay
more info
PubMed 
part_of radial spoke head 2 IDA
Inferred from Direct Assay
more info
PubMed 
part_of radial spoke head 3 IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
radial spoke head protein 4 homolog A
Names
radial spoke head-like protein 3
radial spokehead-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162957.1NP_001156429.1  radial spoke head protein 4 homolog A

    See identical proteins and their annotated locations for NP_001156429.1

    Status: VALIDATED

    Source sequence(s)
    AC153961
    Consensus CDS
    CCDS48534.1
    UniProtKB/Swiss-Prot
    B2RQN0, Q8BYM7
    Related
    ENSMUSP00000131647.2, ENSMUST00000169670.8
    Conserved Domains (1) summary
    pfam04712
    Location:209695
    Radial_spoke; Radial spokehead-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    33781107..33792017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)