U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Catsper2 cation channel, sperm associated 2 [ Mus musculus (house mouse) ]

Gene ID: 212670, updated on 13-Dec-2022

Summary

Official Symbol
Catsper2provided by MGI
Official Full Name
cation channel, sperm associated 2provided by MGI
Primary source
MGI:MGI:2387404
See related
Ensembl:ENSMUSG00000033486 AllianceGenome:MGI:2387404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium activated cation channel activity; calcium channel activity; and voltage-gated ion channel activity. Acts upstream of or within fertilization; flagellated sperm motility; and sperm capacitation. Located in sperm flagellum. Part of CatSper complex. Orthologous to human CATSPER2 (cation channel sperm associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 30.8) and CNS E18 (RPKM 1.2) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Catsper2 in Genome Data Viewer
Location:
2; 2 E5
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121222109..121245082, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121391633..121414598, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33947 Neighboring gene creatine kinase, mitochondrial 1, ubiquitous Neighboring gene stereocilin Neighboring gene protein disulfide isomerase associated 3 Neighboring gene elongation factor RNA polymerase II-like 3 Neighboring gene serine incorporator 4 Neighboring gene small EDRK-rich factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium activated cation channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in fertilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within sperm capacitation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of CatSper complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of CatSper complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cation channel sperm-associated protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153075.3NP_694715.2  cation channel sperm-associated protein 2

    See identical proteins and their annotated locations for NP_694715.2

    Status: VALIDATED

    Source sequence(s)
    AL845466
    Consensus CDS
    CCDS38216.1
    UniProtKB/TrEMBL
    A0A0A0MQ85
    Related
    ENSMUSP00000037222.5, ENSMUST00000038073.5
    Conserved Domains (1) summary
    pfam00520
    Location:105350
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121222109..121245082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499081.5XP_006499144.1  cation channel sperm-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006499144.1

    UniProtKB/TrEMBL
    A0A0A0MQ85
    Conserved Domains (1) summary
    pfam00520
    Location:105350
    Ion_trans; Ion transport protein
  2. XM_030249229.2XP_030105089.1  cation channel sperm-associated protein 2 isoform X3

    Conserved Domains (1) summary
    pfam00520
    Location:105262
    Ion_trans; Ion transport protein
  3. XM_030249227.2XP_030105087.1  cation channel sperm-associated protein 2 isoform X3

    Conserved Domains (1) summary
    pfam00520
    Location:105262
    Ion_trans; Ion transport protein
  4. XM_011239413.4XP_011237715.1  cation channel sperm-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011237715.1

    UniProtKB/TrEMBL
    A0A0A0MQ85
    Conserved Domains (1) summary
    pfam00520
    Location:105350
    Ion_trans; Ion transport protein
  5. XM_030249234.2XP_030105094.1  cation channel sperm-associated protein 2 isoform X7

    Conserved Domains (1) summary
    pfam00520
    Location:105341
    Ion_trans; Ion transport protein
  6. XM_030249233.2XP_030105093.1  cation channel sperm-associated protein 2 isoform X6

    Conserved Domains (1) summary
    pfam00520
    Location:13112
    Ion_trans; Ion transport protein
  7. XM_006499084.5XP_006499147.1  cation channel sperm-associated protein 2 isoform X5

  8. XM_006499082.5XP_006499145.1  cation channel sperm-associated protein 2 isoform X2

    Conserved Domains (1) summary
    pfam00520
    Location:51296
    Ion_trans; Ion transport protein
  9. XM_036160226.1XP_036016119.1  cation channel sperm-associated protein 2 isoform X6

    Conserved Domains (1) summary
    pfam00520
    Location:13112
    Ion_trans; Ion transport protein
  10. XM_017316898.3XP_017172387.1  cation channel sperm-associated protein 2 isoform X7

    Conserved Domains (1) summary
    pfam00520
    Location:105341
    Ion_trans; Ion transport protein
  11. XM_011239414.4XP_011237716.1  cation channel sperm-associated protein 2 isoform X4

    Conserved Domains (1) summary
    pfam00520
    Location:105350
    Ion_trans; Ion transport protein