Nepro nucleolus and neural progenitor protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Neproprovided by MGI
Official Full Name: nucleolus and neural progenitor proteinprovided by MGI
Primary source: MGI:MGI:2384836
See related: Ensembl:ENSMUSG00000036208 AllianceGenome:MGI:2384836
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Acts upstream of or within negative regulation of neuron differentiation and positive regulation of Notch signaling pathway. Located in nucleolus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in anauxetic dysplasia 3. Orthologous to human NEPRO (nucleolus and neural progenitor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 4.9), limb E14.5 (RPKM 4.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16; 16 B4

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (44544664..44560148)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (44724301..44738856)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Nepro is a nucleolus-associated protein, and its loss leads to the apoptosis before blastocyst formation in mice.
Title: Nepro is localized in the nucleolus and essential for preimplantation development in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

General gene information

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Homology

Homologs of the Nepro gene: The Nepro gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 505 organisms have orthologs with human gene Nepro
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nucleolus and neural progenitor protein

Names: neural progenitor protein; protein nepro

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416872.1 → NP_001403801.1 nucleolus and neural progenitor protein isoform 2

Status: VALIDATED

Source sequence(s)

AC122217, AC124180
NM_001416873.1 → NP_001403802.1 nucleolus and neural progenitor protein isoform 3

Status: VALIDATED

Source sequence(s)

AC122217, AC124180
NM_001416874.1 → NP_001403803.1 nucleolus and neural progenitor protein isoform 3

Status: VALIDATED

Source sequence(s)

AC122217, AC124180
NM_145972.5 → NP_666084.1 nucleolus and neural progenitor protein isoform 1

See identical proteins and their annotated locations for NP_666084.1

Status: VALIDATED

Source sequence(s)

AC122217, AC124180

Consensus CDS

CCDS28187.1

UniProtKB/Swiss-Prot

Q8R2U2

UniProtKB/TrEMBL

Q3TS42

Related

ENSMUSP00000038779.8, ENSMUST00000048788.14

Conserved Domains (1) summary

pfam14780
Location:12 → 202

DUF4477; Domain of unknown function (DUF4477)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

44544664..44560148

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521971.5 → XP_006522034.1 nucleolus and neural progenitor protein isoform X1

Conserved Domains (1) summary

pfam14780
Location:22 → 188

DUF4477; Domain of unknown function (DUF4477)
XM_006521972.5 → XP_006522035.1 nucleolus and neural progenitor protein isoform X2

Conserved Domains (1) summary

pfam14780
Location:1 → 105

DUF4477; Domain of unknown function (DUF4477)