U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nepro nucleolus and neural progenitor protein [ Mus musculus (house mouse) ]

Gene ID: 212547, updated on 6-Jun-2024

Summary

Official Symbol
Neproprovided by MGI
Official Full Name
nucleolus and neural progenitor proteinprovided by MGI
Primary source
MGI:MGI:2384836
See related
Ensembl:ENSMUSG00000036208 AllianceGenome:MGI:2384836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Acts upstream of or within negative regulation of neuron differentiation and positive regulation of Notch signaling pathway. Located in nucleolus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in anauxetic dysplasia 3. Orthologous to human NEPRO (nucleolus and neural progenitor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.9), limb E14.5 (RPKM 4.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nepro in Genome Data Viewer
Location:
16 B4; 16 29.04 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44544645..44559994)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44724301..44738856)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40908 Neighboring gene predicted gene, 46571 Neighboring gene VISTA enhancer mm1637 Neighboring gene predicted gene, 30311 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:44692039-44692222 Neighboring gene STARR-seq mESC enhancer starr_40911 Neighboring gene STARR-positive B cell enhancer ABC_E10905 Neighboring gene predicted gene, 30445 Neighboring gene STARR-positive B cell enhancer mm9_chr16:44746411-44746712 Neighboring gene GTP-binding protein 8 (putative) Neighboring gene STARR-positive B cell enhancer ABC_E5543 Neighboring gene CD200 receptor 1 Neighboring gene lactate dehydrogenase A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General protein information

Preferred Names
nucleolus and neural progenitor protein
Names
neural progenitor protein
protein nepro

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416872.1NP_001403801.1  nucleolus and neural progenitor protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122217, AC124180
    UniProtKB/TrEMBL
    Q3TS42
  2. NM_001416873.1NP_001403802.1  nucleolus and neural progenitor protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122217, AC124180
    UniProtKB/TrEMBL
    Q3TS42
  3. NM_001416874.1NP_001403803.1  nucleolus and neural progenitor protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122217, AC124180
    UniProtKB/TrEMBL
    Q3TS42
  4. NM_145972.5NP_666084.1  nucleolus and neural progenitor protein isoform 1

    See identical proteins and their annotated locations for NP_666084.1

    Status: VALIDATED

    Source sequence(s)
    AC122217, AC124180
    Consensus CDS
    CCDS28187.1
    UniProtKB/Swiss-Prot
    Q8R2U2
    UniProtKB/TrEMBL
    Q3TS42
    Related
    ENSMUSP00000038779.8, ENSMUST00000048788.14
    Conserved Domains (1) summary
    pfam14780
    Location:12202
    DUF4477; Domain of unknown function (DUF4477)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    44544645..44559994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)