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EVI2B ecotropic viral integration site 2B [ Homo sapiens (human) ]

Gene ID: 2124, updated on 22-Sep-2022

Summary

Official Symbol
EVI2Bprovided by HGNC
Official Full Name
ecotropic viral integration site 2Bprovided by HGNC
Primary source
HGNC:HGNC:3500
See related
Ensembl:ENSG00000185862 MIM:158381; AllianceGenome:HGNC:3500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EVDB; CD361; D17S376
Summary
Involved in positive regulation of granulocyte differentiation. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 78.2), spleen (RPKM 77.3) and 15 other tissues See more
Orthologs
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Genomic context

See EVI2B in Genome Data Viewer
Location:
17q11.2
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (31303770..31314054, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (32249455..32259731, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29630788..29641072, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene uncharacterized LOC101927057 Neighboring gene oligodendrocyte myelin glycoprotein Neighboring gene ecotropic viral integration site 2A Neighboring gene adenylate kinase 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ecotropic viral integration site 2B (EVI2B) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in myeloid cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of granulocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of granulocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neutrophil differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of neutrophil differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of stem cell division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of stem cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein EVI2B
Names
EVI-2B
ecotropic viral integration site 2B protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006495.4NP_006486.3  protein EVI2B precursor

    See identical proteins and their annotated locations for NP_006486.3

    Status: VALIDATED

    Source sequence(s)
    AA251185, AW576194, BC005926
    Consensus CDS
    CCDS11266.1
    UniProtKB/Swiss-Prot
    B7Z4A7, P34910
    UniProtKB/TrEMBL
    Q9BRW1
    Related
    ENSP00000333779.4, ENST00000330927.5
    Conserved Domains (1) summary
    cl10080
    Location:122208
    RPE65; Retinal pigment epithelial membrane protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    31303770..31314054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791803.1 Reference GRCh38.p14 PATCHES

    Range
    382932..393208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    32249455..32259731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)